Results 21 to 30 of about 17,484 (210)
CDK5: Key Regulator of Apoptosis and Cell Survival
Biomedicines, 2019 The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator p35,
Rabih Roufayel, Nimer Murshid
exaly +3 more sources
The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer [PDF]
CellsCyclin-dependent kinase 5 (Cdk5) is an atypical serine/threonine kinase distinct from classical cell cycle regulators. Its activity is highest in the nervous system and essential for development, but its functions in other tissues, particularly in cancer,
Yoshiaki V. Nishimura, Takeshi Kawauchi
doaj +2 more sources
HPV18E6 and CDK5 virus-host interaction is a prospective therapeutic target for HPV-positive cervical cancer [PDF]
Tumour Virus ResearchThe E6 oncoprotein encoded by the cancer-causing human papillomavirus (HPV) is vital for maintaining the ability of the virus to promote cell proliferation and cancer progression.
Chuanyun Xiao +4 more
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CDK5 downregulation enhances synaptic plasticity [PDF]
Cellular and Molecular Life Sciences, 2016 CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation has been associated with Tau hyperphosphorylation and cognitive deficits.
Rafael Andrés Posada-Duque +7 more
openaire +8 more sources
All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation
Cellular Physiology and Biochemistry, 2014 Background/Aims: All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells.
Eugene Lin +7 more
doaj +2 more sources
Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s Disease [PDF]
BiomoleculesProtein kinases are important molecules of Alzheimer’s Disease (AD), driving neuronal demise and the emergence of the disease’s destructive hallmarks. Cdk5 has recently been highlighted as a key therapeutic target for AD.
Sakshi Kumari +9 more
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Cdk5: a multifaceted kinase in neurodegenerative diseases
Trends in Cell Biology, 2012 Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an array of neurodegenerative diseases. As knowledge on the etiopathological mechanisms of these diseases evolved through the years, Cdk5 has also been implicated in additional ...
Cheung, Zelda H., Ip, Nancy Y.
openaire +5 more sources
Cells, 2021 Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold +9 more
doaj +1 more source
Open Chemistry, 2021 Pit-1 (POU1F1) is a POU-homeodomain transcription factor, and it is one of the most important tissue-specific transcription factors in pituitary development.
Xie Weiyan +5 more
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