Results 31 to 40 of about 17,484 (210)
Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein [PDF]
Cell Cycle, 2010 (2010). Cdk5 variant 1 (cdk5-v1), but not full-length cdk5, is a centrosomal protein. Cell Cycle: Vol. 9, No. 11, pp. 2251-2253.
Tom, Kim +3 more
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CDK5: an oncogene or an anti-oncogene: location location location
Molecular Cancer, 2023 Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
doaj +1 more source
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
Frontiers in Pharmacology, 2022 Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and ...
Alan Umfress +11 more
doaj +1 more source
CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation
Cancer Medicine, 2021 The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has
Qiaoyun Chu +4 more
doaj +1 more source
, 2023 The role of cyclin-dependent kinase 5 (Cdk5) in the normal functioning of the central nervous system and synaptic plasticity is well established. However, dysregulated kinase activity can have a significant impact on neurodegeneration and cognitive ...
Archana Singh (178445) +13 more
core +1 more source
Regulation of Kalirin by Cdk5 [PDF]
Journal of Cell Science, 2008 Kalirin, one of the few Rho guanine nucleotide exchange factors (GEFs) that contains spectrin-like repeats, plays a critical role in axon extension and maintenance of dendritic spines. PC12 cells were used to determine whether Cdk5, a critical participant in both processes, regulates the action of Kalirin.
Xiaonan, Xin +6 more
openaire +2 more sources
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
core +1 more source
Cdk5, the multifunctional surveyor [PDF]
Cell Cycle, 2010 Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by Cdk5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. Here, we review
Vassiliki, Lalioti +2 more
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Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš +17 more
core +1 more source
Cell Adhesion & Migration, 2010 Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell.
Brajendra K, Tripathi, Peggy S, Zelenka
openaire +2 more sources