Results 41 to 50 of about 17,484 (210)

Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice

Frontiers in Molecular Neuroscience, 2018
Cyclin-dependent kinase 5 (CDK5) is abundantly expressed in post-mitotic cells including neurons. It is involved in multiple cellular events, such as cytoskeletal dynamics, signaling cascades, gene expression, and cell survival, et al.
Xiaoyan Zhai, Chengcheng Liu, Chengcheng Liu, Bin Zhao, Yanfei Wang, Zhigang Xu, Zhigang Xu, Zhigang Xu   +7 more
doaj   +1 more source

Computational Simulations Identified Two Candidate Inhibitors of Cdk5/p25 to Abrogate Tau-associated Neurological Disorders

Computational and Structural Biotechnology Journal, 2019
Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults.
Amir Zeb, Minky Son, Sanghwa Yoon, Ju Hyun Kim, Seok Ju Park, Keun Woo Lee   +5 more
doaj   +1 more source

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke [PDF]

, 2018
CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25. Here we reported that CDK5-Tyr15 phosphorylation by zinc induced CDK5 activation in brain ischemic injury ...
Lei, P, Liang, JW, Liuyang, ZY, Zhou, XW, Pei, L, Tuo, QZ, Hou, TY, Liu, R, Wang, JZ, Shentu, YP, Xiong, Y, Wang, XC, Yan, X, Zhou, H, Wang, Q   +14 more
core   +1 more source

CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.

PLoS ONE, 2015
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells.
Shu Zhang, Zhen Lu, Weiqun Mao, Ahmed A Ahmed, Hailing Yang, Jinhua Zhou, Nicholas Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Roberto Miranda, Wei Qiao, Veera Baladandayuthapani, Zongfang Li, Anil K Sood, Jinsong Liu, Xiao-Feng Le, Robert C Bast   +16 more
doaj   +1 more source

Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy

Journal of Diabetes Investigation, 2022
Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano, Kazuhiko Namekata, Masanori Niki, Kentaro Semba, Fumiko Murao, Takayuki Harada, Yoshinori Mitamura   +6 more
doaj   +1 more source

Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders

Frontiers in Molecular Neuroscience, 2022
Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian, Bin Feng, Xing-Qin Wang, Jiao Tian   +3 more
doaj   +1 more source

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

Bone Research, 2022
Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified
Mubashir Ahmad, Benjamin Thilo Krüger, Torsten Kroll, Sabine Vettorazzi, Ann-Kristin Dorn, Florian Mengele, Sooyeon Lee, Sayantan Nandi, Dilay Yilmaz, Miriam Stolz, Naveen Kumar Tangudu, David Carro Vázquez, Johanna Pachmayr, Ion Cristian Cirstea, Maja Vujic Spasic, Aspasia Ploubidou, Anita Ignatius, Jan Tuckermann   +17 more
doaj   +1 more source

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo [PDF]

, 2013
The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of its truncated activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid deposition, and neuronal death in vitro and in vivo ...
Pant, Harish C., Sundaram, Jeyapriya Raja, Poore, Charlene Priscilla, Asad, A. B. M. A., Rajkumar, Ramamoorthy, Dawe, Gavin Stewart, Wenk, Markus R., Kesavapany, Sashi, Bin Sulaimee, Noor Hazim, Pareek, Tej, Cheong, Wei Fun, Chuang, Kai-Hsiang   +11 more
core   +1 more source

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson′s disease

Neural Regeneration Research, 2016
Cyclin-dependent kinase 5 (Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions.
B K Binukumar, Harish C Pant
doaj   +1 more source

Cdk5 in Neuroskeletal Dynamics [PDF]

Neurosignals, 2003
Signal transduction in a broad sense refers to intracellular, molecular changes triggered by cues outside the cell in order to bring about behavioral responses such as migration, differentiation, secretion, or death. Until recently, the best-studied end targets of signal transduction pathways were transcriptional regulators that contribute to changes ...
openaire   +2 more sources