Results 61 to 70 of about 17,484 (210)

Long and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer´s mice

Frontiers in Aging Neuroscience, 2014
CDK5 is a member of the cyclin-dependent kinase family with diverse functions in both the developing and mature nervous system. The inappropriate activation of CDK5 due to the proteolytic release of the activator fragment p25 from the membrane ...
John Fredy Castro-Alvarez, Sergio Alejandro Uribe-Arias, Kenneth S Kosik, Gloria Patricia eCardona-Gomez   +3 more
doaj   +1 more source

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. [PDF]

PLoS ONE, 2015
Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases.
Bo S Kim, Leonid Serebreni, Jonathan Fallica, Omar Hamdan, Lan Wang, Laura Johnston, Todd Kolb, Mahendra Damarla, Rachel Damico, Paul M Hassoun   +9 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Deregulation of cdk5 in Hippocampal Sclerosis [PDF]

Journal of Neuropathology and Experimental Neurology, 2006
Hippocampal sclerosis (HS) is the most common cause of chronic medically refractory epilepsy in adults. Histologically, HS is characterized by segmental neuronal loss and gliosis. Although neuronal loss is important to the pathophysiology of HS, the molecular mechanisms underlying the neuronal loss remain uncertain.
Sen, A, Thom, M, Martinian, L, Jacobs, T, Nikolic, M, Sisodiya, S   +5 more
openaire   +3 more sources

Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth [PDF]

, 2000
Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates.
Van Etten, R A, Humbert, Sandrine, Wu, Chin-Lee, Lanier, Lorene M, Nikolic, Margareta, Gertler, Frank, Vidal, Marc, Zukerberg, L R, Lanier, Lorene M., Gertler, F B, Nikolic, M, Van Etten, Richard A, Tsai, Li-Huei, Tsai, L H, Patrick, Gentry N, Zukerberg, Lawrence R, Humbert, S, Patrick, G N, Wu, C L, Lanier, L M, Vidal, M, Gertler, Frank B   +21 more
core   +1 more source

Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening

Journal of Biomedical Science, 2009
Background Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and well ...
Hiller Gösta, Malmström Jonas, Ottervald Jan, Radesäter Ann-Cathrin, Agerman Karin, Jämsä Anne, Liu Gang, Vasänge Mervi   +7 more
doaj   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

PROTEOMICS, EarlyView.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren, Kenneth Weke, Darryl Hardie, Mariya I. Goncheva, Ted Hupp, Javier Antonio Alfaro, Helena Pětrošová, David R. Goodlett   +7 more
wiley   +1 more source

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Neurosignals, 2012
Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y. Ip   +4 more
doaj   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Frontiers in Cellular Neuroscience, 2013
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto   +9 more
doaj   +1 more source