Results 1 to 10 of about 27,357 (213)
Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity
NeuroMolecular Medicine, 2014 Cyclin-dependent kinase (Cdk) 5 is critical for central nervous system development and neuron-specific functions including neurite outgrowth as well as synaptic function and plasticity. Cdk5 activity requires association with one of the two regulatory subunits, called p35 and p39. p35 redistribution as well as misregulation of Cdk5 activity is followed
Jochen Weishaupt +2 more
exaly +5 more sources
New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization
Viruses, 2022 Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral immune response induced by this virus.
Yana Khlusevich +6 more
doaj +2 more sources
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
doaj +2 more sources
Molecular Therapy: Nucleic Acids, 2022 Existing studies have revealed that microRNAs (miRNAs) have a role in cognitive deficits in Alzheimer’s disease (AD). However, the function and pathophysiological mechanism of deregulated miRNAs underlying AD pathology remain to be investigated.
Li Zeng +8 more
doaj +2 more sources
Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5. [PDF]
PLoS ONE, 2015 p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse ...
Shunsuke Takada +5 more
doaj +6 more sources
Molecular Brain, 2022 Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi +9 more
doaj +2 more sources
Cell Reports, 2018 Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Kai Zhuang +18 more
doaj +2 more sources
Acta Neuropathologica Communications, 2019 Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz +8 more
doaj +2 more sources
Salidroside derivative SHPL-49 enhances synaptic remodeling in BCCAO rats via the CDK5/p35/p25 signaling pathway [PDF]
Frontiers in PharmacologyBackgroundIn recent years, significant attention has been directed toward the development of therapeutic agents targeting cognitive and motor dysfunction following ischemic stroke.
Pei Zhang +6 more
doaj +2 more sources
Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. [PDF]
PLoS ONE, 2014 The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35.
Samadhi Aparicio-Siegmund +10 more
doaj +2 more sources