Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages [PDF]
Frontiers in ImmunologyIntroductionMacrophage polarization into M1 or M2 phenotypes is a complex process influenced by various factors. However, existing literature and ongoing research support the view that Cyclin-Dependent Kinase 5 (CDK5) may play an important role in this ...
Juliana R. Zampieri +9 more
doaj +4 more sources
Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5. [PDF]
PLoS ONE, 2015 p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse ...
Shunsuke Takada +5 more
doaj +3 more sources
The Shared IL‐12/IL‐35 p35 Subunit Is Associated With Heightened Atherogenic Risk in African Patients With Type 2 Diabetes [PDF]
Endocrinology, Diabetes & MetabolismIntroduction Interleukin (IL)‐12 and IL‐35 are heterodimeric cytokines that share the p35 subunit and have opposing inflammatory roles. Dysregulated IL‐12/IL‐35 p35 may reflect an imbalance between pro‐ and anti‐inflammatory pathways linking metabolic ...
Tawanda M. Nyambuya +3 more
doaj +2 more sources
New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization
Viruses, 2022 Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral immune response induced by this virus.
Elena A Goncharova +2 more
exaly +3 more sources
Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex. [PDF]
EpilepsiaAbstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Guo D +4 more
europepmc +2 more sources
Salidroside derivative SHPL-49 enhances synaptic remodeling in BCCAO rats via the CDK5/p35/p25 signaling pathway [PDF]
Frontiers in PharmacologyBackgroundIn recent years, significant attention has been directed toward the development of therapeutic agents targeting cognitive and motor dysfunction following ischemic stroke.
Pei Zhang +6 more
doaj +2 more sources
Cell Reports, 2018 Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Huaxi Xu, Honghua Zheng, Hao Sun
exaly +3 more sources
Microbial Community Succession During Bioremediation of Petroleum-Contaminated Soils Using Rhodococcus sp. OS62-1 and Pseudomonas sp. P35 [PDF]
MicroorganismsOil pollution poses a persistent threat to soil ecosystems globally, and bioremediation using bacterial consortia has emerged as a cost-effective remediation strategy.
Xiaodong Liu +5 more
doaj +2 more sources
Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
doaj +1 more source
Characterization and Evaluation of a Novel Conserved Membrane Antigen P35 of Mycoplasma synoviae
Frontiers in Veterinary Science, 2022 Mycoplasma synoviae (MS) is a major avian pathogen that causes respiratory damage, infectious synovitis, and arthritis in chickens and causes serious economic losses to the global poultry industry. Despite its significance, knowledge on pathogenicity and
Qianjin Sun +11 more
doaj +1 more source