New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization
Viruses, 2022 Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral immune response induced by this virus.
Yana A Khlusevich +2 more
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Salidroside derivative SHPL-49 enhances synaptic remodeling in BCCAO rats via the CDK5/p35/p25 signaling pathway [PDF]
Frontiers in PharmacologyBackgroundIn recent years, significant attention has been directed toward the development of therapeutic agents targeting cognitive and motor dysfunction following ischemic stroke.
Pei Zhang +6 more
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Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages [PDF]
Frontiers in ImmunologyIntroductionMacrophage polarization into M1 or M2 phenotypes is a complex process influenced by various factors. However, existing literature and ongoing research support the view that Cyclin-Dependent Kinase 5 (CDK5) may play an important role in this ...
Juliana R. Zampieri +9 more
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Cell Reports, 2018 Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Kai Zhuang +2 more
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A novel mineralization-inductive peptide derived from CEMP1functinal domains [PDF]
Scientific ReportsA novel biomimetic peptide (P35) was designed and synthesized by combining the N-terminal 20 amino acids and the C-terminal 15 amino acids of cementum protein 1 (CEMP1), guided by molecular docking and plasmid-based molecular engineering (sequence ...
Yu Wang +4 more
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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5. [PDF]
PLoS ONE, 2015 p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse ...
Shunsuke Takada +5 more
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Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
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Characterization and Evaluation of a Novel Conserved Membrane Antigen P35 of Mycoplasma synoviae
Frontiers in Veterinary Science, 2022 Mycoplasma synoviae (MS) is a major avian pathogen that causes respiratory damage, infectious synovitis, and arthritis in chickens and causes serious economic losses to the global poultry industry. Despite its significance, knowledge on pathogenicity and
Qianjin Sun +11 more
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Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. [PDF]
PLoS ONE, 2014 The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35.
Samadhi Aparicio-Siegmund +10 more
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Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria. [PDF]
PLoS ONE, 2012 Many insect viruses express caspase inhibitors of the P35 superfamily, which prevent defensive host apoptosis to enable viral propagation. The prototypical P35 family member, AcP35 from Autographa californica M nucleopolyhedrovirus, has been extensively ...
Ingo L Brand +9 more
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