Results 21 to 30 of about 25,694 (216)

An improved luciferase immunosorbent assay for ultrasensitive detection of antibodies against African swine fever virus

Frontiers in Microbiology, 2022
African swine fever (ASF), caused by African swine fever virus (ASFV), is a fatal infectious disease of pigs and causes great socioeconomic losses globally. The reliable diagnostic method is critical for prevention and control of the disease.
Qiongjie Wang, Zhancheng Tian, Jifei Yang, Shandian Gao, Junzheng Du, Hongge Zhang, Zhonghui Zhang, Guiquan Guan, Qingli Niu, Hong Yin, Hong Yin   +10 more
doaj   +1 more source

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study

Frontiers in Neurology, 2018
Mild traumatic brain injuries (mTBI) are common during adolescence, and limited clinical evidence suggests that a younger age at first exposure to a mTBI may lead to worse long-term outcomes.
Thomas J. McColl, Rhys D. Brady, Rhys D. Brady, Rhys D. Brady, Sandy R. Shultz, Sandy R. Shultz, Lauren Lovick, Kyria M. Webster, Mujun Sun, Stuart J. McDonald, Terence J. O’Brien, Terence J. O’Brien, Bridgette D. Semple, Bridgette D. Semple   +13 more
doaj   +1 more source

Paragangliome retropéritonéal: à propos d'un cas et revue de littérature

The Pan African Medical Journal, 2015
Les paragangliomes rétropéritonéaux non fonctionnels sont des tumeurs rares. Ils sont définis comme des tumeurs chromaffines extra- surrénaliennes et représentent environ 1/5ème des tumeurs chromaffines.
Yassine Fahmi, Tawfik Elabbasi, Driss Khaiz, Fatima Zahra Bensardi, Khaled Hattabi, Saad Berrada, Rachid Lefriyekh, Abdelaziz Fadil, Najib Zerouali   +8 more
doaj   +1 more source

Hepatic fascioliasis presenting with bile duct obstruction: a case report

The Pan African Medical Journal, 2017
Fascioliasis is a zoonotic infection caused by a liver trematode: fasciola hepatica; which commonly affects cattle and sheep, humans are accidental hosts. Several cases have been reported in the literature worldwide with a large geographical distribution.
Rachid Lefriyekh, Ahmed Bensaad, Fatimazahra Bensardi, Khalid Elhattabi, Mounir Bouali, Bessam Daif, Abdelaziz Fadil, Zakaria Jouahari, Tazi Hicham, Aziz Hamdani, Maha Soussi Abdalaoui   +10 more
doaj   +1 more source

Expression of the Baculovirus p35 Protein in Tobacco Affects Cell Death Progression and Compromises N Gene-Mediated Disease Resistance Response to Tobacco mosaic virus

Molecular Plant-Microbe Interactions, 2003
The p35 protein from baculovirus is a broad-range caspase inhibitor and suppresses programmed cell death in animals. We report here the effects of transgenic expression in tobacco of the p35 protein during the hypersensitive response (HR).
Olga del Pozo, Eric Lam
doaj   +1 more source

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease

Molecular Therapy: Nucleic Acids, 2022
Existing studies have revealed that microRNAs (miRNAs) have a role in cognitive deficits in Alzheimer’s disease (AD). However, the function and pathophysiological mechanism of deregulated miRNAs underlying AD pathology remain to be investigated.
Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Liu   +8 more
doaj   +1 more source

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide⁺

BMC Cancer, 2010
Background Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism.
Doloff Joshua C, Su Ting, Waxman David J
doaj   +1 more source

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Frontiers in Cellular Neuroscience, 2020
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of
YaLi Wang, JianHua Zhao, Fang-Li Guo, XiaHuan Gao, Xine Xie, ShouQing Liu, Xin Yang, XinFeng Yang, LuYi Zhang, YuXiao Ye, LiBing Fan, JianGang Wang, JianGang Wang, JianGang Wang, JianGang Wang   +14 more
doaj   +1 more source

The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development

Cells, 2021
Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold, Jeffrey Pippin, David Unnersjoe-Jess, Sybille Koehler, Stuart Shankland, Sebastian Brähler, Bernhard Schermer, Thomas Benzing, Paul T. Brinkkoetter, Henning Hagmann   +9 more
doaj   +1 more source

CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5 [PDF]

, 2008
Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a ...
林圣彩, LinSheng-Cai, LinShuyong, IpNancyY, WangJifeng, YeZhiyun   +5 more
core   +2 more sources