Results 31 to 40 of about 25,694 (216)

Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders

Frontiers in Molecular Neuroscience, 2022
Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian, Bin Feng, Xing-Qin Wang, Jiao Tian   +3 more
doaj   +1 more source

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Acta Neuropathologica Communications, 2019
Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller   +8 more
doaj   +1 more source

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
core   +1 more source

alpha 2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells

, 2001
Neuronal differentiation involves Rac and Cdc42 GTPases. alpha -Chimaerin, a Rac/Cdc42 regulator, occurs as alpha 1- and alternatively spliced Src homology 2 (SH2) domain-containing alpha 2-isoforms. alpha 2-chimaerin mRNA was highly expressed in the rat
Christine Hall, Giovanna Ferrari, Nansi Cann, Teo, M., Clinton Monfries, Michael, G.J., Cann, N., Louis Lim, Ferrari, G., Jacobs, T., Mabel Teo, Hall, C., Tom Jacobs, Lim, L., Gregory J. Michael, Monfries, C.   +15 more
core   +1 more source

p35 interacts with NIF-1.

, 2014
(A) Mouse NIF-1 encodes a 1,291-amino acid protein and contains 6 zinc finger domains, an LXXLL domain, and a leucine zipper-like motif. (B & C) Mapping of interaction domains between NIF-1 and p35.
Winnie W. Y. Chien (645660), Wing-Yu Fu (645659), Xiao-su Zhao (386365), Amy K. Y. Fu (645661), Zhen Li (49109), Nancy Y. Ip (255933)   +5 more
core   +1 more source

Intergovernmental Fiscal Transfers and Tax Collection of Indian States: Estimation from Panel Data Models

Acta Universitatis Sapientiae: Economics and Business, 2023
This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
doaj   +1 more source

The neuroprotective effects of virally-derived caspase inhibitors p35 and crmA following a necrotic insult

Neurobiology of Disease, 2003
Neuronal excitotoxicity causes energetic impairment and the ensuing cell death has historically been regarded as necrotic. Recent findings, however, indicate that apoptosis may participate in excitotoxicity.
Madhuri Roy, Robert M Sapolsky
doaj   +1 more source

Three decades of Cdk5

Journal of Biomedical Science, 2021
Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function.
Ping-Chieh Pao, Li-Huei Tsai
doaj   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, Accepted Article.
Background Type I interferonopathies are heterogeneous diseases driven by dysregulated IFN‐I signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. Objective To characterize the clinical, immunological, genetic, molecular profiles of patients with suspected enhanced IFN‐I signaling, and assess ...
Ismail Yaz, Seza Ozen, Hacer N. Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet E. Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet O. Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Binding of AATYK1A to Cdk5/p35.

, 2013
(A) Coimmunoprecipitation of Cdk5/p35 with AATYK1A in HEK293 cells. AATYK1A-Flag was coexpressed with p35 and/or Cdk5 in HEK293 cells and immunoprecipitated from cell lysates using the anti-Flag antibody.
Koji Tsutsumi (365453), Shin-ichi Hisanaga (177755), Tetsuya Takano (365454), Ryo Endo (365455), Mitsunori Fukuda (87862), Mineko Tomomura (365456), Toshio Ohshima (154229)   +6 more
core   +1 more source