Results 51 to 60 of about 25,694 (216)

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Transfection of p35 induces podocyte differentiation.

, 2016
The p35 gene and empty vector (EV) were infected into cultured podocyte (day 1). After 48h incubation, cells were fixed or harvested for further detection of p35 and synaptopodin by immunofluorescence and western blots. A.
Xiao-Hua Lu (454839), Varsha Shukla (454841), Niranjana D. Amin (454842), Jing E (2901434), Ya-Li Zheng (454837), Xia Zhang (41398), Bo Li (112195), Li Bao (323211), Hong-Yan Luo (454840), Yong-Cai Gao (2901428), Hai-Xia Fu (2901431), Mei Guo (162920)   +11 more
core   +1 more source

Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

Neurobiology of Disease, 2012
Epidemiological study reveals that socially isolated persons have increased risk of developing Alzheimer's disease (AD). Whether this risk arises from an oxidative stress is unclear.
Ya-Hsin Hsiao, Jinn-Rung Kuo, Shun-Hua Chen, Po-Wu Gean   +3 more
doaj   +1 more source

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +1 more source

Digital twin quantifies spatial‐heterogeneity‐driven failure in fast‐charging lithium‐ion battery anodes

InfoMat, EarlyView.
This work constructs a series of graphite anodes with systematically varied binder distribution, porosity, and electrode thickness to resolve the role of microstructural heterogeneity during fast charging. The digital twin framework reveals how phase‐level structural gradients govern Li plating, SEI formation, and diffusion‐induced stresses, providing ...
Yejin Kang, Seungsoo Jang, Jung Hyeon Moon, EunAe Cho, Kang Taek Lee   +4 more
wiley   +1 more source

Cdk5/p35 Expression in the Mouse Ovary

Molecules and Cells, 2004
Cyclin-dependent kinase 5 (Cdk5) is primarily associated with brain development but it is also implicated in lens and muscle differentiation. We found that Cdk5 is also expressed in mouse ovary, and explored the possibility that it plays a role in that tissue.
Kyoung-Youl, Lee, Jesusa L, Rosales, Byung-Chul, Lee, Seung-Hyuk, Chung, Yoshihiro, Fukui, Nam-Seob, Lee, Ki-Young, Lee, Young-Gil, Jeong   +7 more
openaire   +2 more sources

Screening the receptors for Mycoplasma penetrans P35 lipoprotein and characterization of its functional binding domains

Frontiers in Cellular and Infection Microbiology
Mycoplasma penetrans, a prokaryotic microorganism initially isolated from the urine of a patient infected with human immunodeficiency virus (HIV), possesses a distinctive elongated flask-like shape and a tip-like structure.
Xia Li, Xiaoliu Wang, Youyuan Ye, Zhuo Zeng, Li Chen, Kailan Peng, Hua Xiao, Siqi Gao, Haodang Luo, Yanhua Zeng, Yanhua Zeng   +10 more
doaj   +1 more source

Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability

Frontiers in Cellular Neuroscience, 2018
p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease.
Eriko Kamiki, Eriko Kamiki, Roman Boehringer, Denis Polygalov, Toshio Ohshima, Thomas J. McHugh   +5 more
doaj   +1 more source

Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. [PDF]

PLoS ONE, 2010
Apoptosis-associated tyrosine kinase 1 (AATYK1), a novel serine/threonine kinase that is highly expressed in the brain, is involved in neurite extension and apoptosis of cerebellar granule neurons; however, its precise function remains unknown.
Koji Tsutsumi, Tetsuya Takano, Ryo Endo, Mitsunori Fukuda, Toshio Ohshima, Mineko Tomomura, Shin-ichi Hisanaga   +6 more
doaj   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source