Results 51 to 60 of about 27,357 (213)

Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model

Neurobiology of Disease, 2012
Epidemiological study reveals that socially isolated persons have increased risk of developing Alzheimer's disease (AD). Whether this risk arises from an oxidative stress is unclear.
Ya-Hsin Hsiao, Jinn-Rung Kuo, Shun-Hua Chen, Po-Wu Gean   +3 more
doaj   +1 more source

p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing

Journal of Neurochemistry, 2015
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment.
Rafael Posada-Duque, Alejandro López-Tobón, D. Piedrahita, C. González-Billault, G. Cardona-Gómez   +4 more
semanticscholar   +1 more source

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Screening the receptors for Mycoplasma penetrans P35 lipoprotein and characterization of its functional binding domains

Frontiers in Cellular and Infection Microbiology
Mycoplasma penetrans, a prokaryotic microorganism initially isolated from the urine of a patient infected with human immunodeficiency virus (HIV), possesses a distinctive elongated flask-like shape and a tip-like structure.
Xia Li, Xiaoliu Wang, Youyuan Ye, Zhuo Zeng, Li Chen, Kailan Peng, Hua Xiao, Siqi Gao, Haodang Luo, Yanhua Zeng, Yanhua Zeng   +10 more
doaj   +1 more source

Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability

Frontiers in Cellular Neuroscience, 2018
p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease.
Eriko Kamiki, Eriko Kamiki, Roman Boehringer, Denis Polygalov, Toshio Ohshima, Thomas J. McHugh   +5 more
doaj   +1 more source

Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. [PDF]

PLoS ONE, 2010
Apoptosis-associated tyrosine kinase 1 (AATYK1), a novel serine/threonine kinase that is highly expressed in the brain, is involved in neurite extension and apoptosis of cerebellar granule neurons; however, its precise function remains unknown.
Koji Tsutsumi, Tetsuya Takano, Ryo Endo, Mitsunori Fukuda, Toshio Ohshima, Mineko Tomomura, Shin-ichi Hisanaga   +6 more
doaj   +1 more source

Microtubule Association of the Neuronal p35 Activator of Cdk5 [PDF]

Journal of Biological Chemistry, 2007
Cdk5 and its neuronal activator p35 play an important role in neuronal migration and proper development of the brain cortex. We show that p35 binds directly to alpha/beta-tubulin and microtubules. Microtubule polymers but not the alpha/beta-tubulin heterodimer block p35 interaction with Cdk5 and therefore inhibit Cdk5-p35 activity.
Hou, Z., Li, Q., He, L., Lim, H.-Y., Fu, X., Nam, S.C., Qi, D.X., Qi, R.Z.   +7 more
openaire   +3 more sources

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

Epilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi, Umberto Costantino, Maria Teresa Di Claudio, Carmela Pia Ferro, Pietro Palumbo, Mario Benvenuto, Massimiliano Copetti, Leonardo D'Agruma, Massimo Carella, Marco Castori, Orazio Palumbo   +10 more
wiley   +1 more source

A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. [PDF]

PLoS ONE, 2016
The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary cytokine that drives CD4+ T-cell Th1 differentiation is interleukin (IL)-12 p70,
Chido Loveness Kativhu, Daniel H Libraty
doaj   +1 more source

Seismic Performance and Vibration‐Based Damage Identification of Two‐Storey Balloon‐Framed CLT Shear Walls

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT While cross‐laminated timber (CLT) is increasingly utilized in lateral force‐resisting systems in mass timber construction, research has predominantly focused on platform‐type construction. Balloon‐type CLT shear wall systems offer distinct structural advantages, notably the elimination of cumulative perpendicular‐to‐grain compression and a ...
Samira Mohammadyzadeh, Houman Ganjali, Jianhui Zhou, Thomas Tannert   +3 more
wiley   +1 more source