Results 61 to 70 of about 27,357 (213)

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination*

Journal of Biological Chemistry, 2015
Cdk5 is a versatile protein kinase that is involved in various neuronal activities, such as the migration of newborn neurons, neurite outgrowth, synaptic regulation, and neurodegenerative diseases. Cdk5 requires the p35 regulatory subunit for activation.
Toshiyuki Takasugi, Seiji Minegishi, A. Asada, Taro Saito, H. Kawahara, S. Hisanaga   +5 more
semanticscholar   +1 more source

Recyclable Printed Liquid Metal Composite for Underwater Stretchable Electronics

Small Science, Volume 5, Issue 5, May 2025.
This work presents a multifunctional liquid metal (LM) microdroplet‐based composite with a custom‐designed block copolymer as the matrix, optimized for printing. The composite exhibits high conductivity, stretchability, durability in dry and aqueous environments, and recyclability of LM using green solvents. These properties highlight its potential for
Chi‐hyeong Kim, Jinsil Kim, Jiaxin Fan, Meijing Wang, Fabio Cicoira   +4 more
wiley   +1 more source

Physiological and pathological phosphorylation of tau by Cdk5

Frontiers in Molecular Neuroscience, 2014
Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, including Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-
Taeko eKimura, Koichi eIshiguro, Shin-Ichi eHisanaga   +2 more
doaj   +1 more source

The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration. [PDF]

PLoS ONE, 2011
CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function ...
Silvia Moncini, Alessandro Salvi, Paola Zuccotti, Gabriella Viero, Alessandro Quattrone, Sergio Barlati, Giuseppina De Petro, Marco Venturin, Paola Riva   +8 more
doaj   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. [PDF]

PLoS ONE, 2014
Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.
Kazuya Tanabe, Hiroyuki Yamazaki, Yutaka Inaguma, Akiko Asada, Taeko Kimura, Junya Takahashi, Masato Taoka, Toshio Ohshima, Teiichi Furuichi, Toshiaki Isobe, Koh-ichi Nagata, Tomoaki Shirao, Shin-ichi Hisanaga   +12 more
doaj   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, EarlyView.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

p35 Is Required for CDK5 Activation in Cellular Senescence [PDF]

Journal of Biological Chemistry, 2010
The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence. Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in senescence-like changes. The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the best known function of which is in neuronal development ...
Daqin, Mao, Philip W, Hinds
openaire   +2 more sources

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Simultaneous reduction of dietary protein and daily feeding rate in biofloc system: Effect on water quality, growth, digestive and antioxidant capacity, immune response, and resistance to Aeromonas hydrophila in common carp

Aquaculture Reports
This experiment evaluated the impacts of simultaneous reduction of dietary protein and daily feeding rate in a biofloc system on performance of common carp, Cyprinus carpio.
Hossein Adineh, Mahdi Naderi, Mohammad Amini Chermahini, Golbahar Zeitounli, Mohammad Meysam Salahi Ardekani   +4 more
doaj   +1 more source