Results 61 to 70 of about 25,694 (216)

A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. [PDF]

PLoS ONE, 2016
The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary cytokine that drives CD4+ T-cell Th1 differentiation is interleukin (IL)-12 p70,
Chido Loveness Kativhu, Daniel H Libraty
doaj   +1 more source

Recyclable Printed Liquid Metal Composite for Underwater Stretchable Electronics

Small Science, Volume 5, Issue 5, May 2025.
This work presents a multifunctional liquid metal (LM) microdroplet‐based composite with a custom‐designed block copolymer as the matrix, optimized for printing. The composite exhibits high conductivity, stretchability, durability in dry and aqueous environments, and recyclability of LM using green solvents. These properties highlight its potential for
Chi‐hyeong Kim, Jinsil Kim, Jiaxin Fan, Meijing Wang, Fabio Cicoira   +4 more
wiley   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Depletion of Rho/Rok/Myosin suppresses proliferation following junctional complex disruption + P35, and promotes proliferation following basolateral complex disruption + P35.

, 2016
Confocal immunofluorescent localization of DE-cadherin, GFP, and MMP1 in wing discs expressing GFP with P35 alone (Aa and Ab), Cdc42-RNAi and P35 (Ba and Bb), Cdc42-RNAi and P35 in a rho172F heterozygous background (Ca and Cb), and Cdc42-RNAi and P35 in ...
Gregory D. Longmore (2889197), Gregory V. Schimizzi (246497), Andrew J. Loza (2889200), Meghan T. Maher (250262)   +3 more
core   +1 more source

Physiological and pathological phosphorylation of tau by Cdk5

Frontiers in Molecular Neuroscience, 2014
Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, including Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-
Taeko eKimura, Koichi eIshiguro, Shin-Ichi eHisanaga   +2 more
doaj   +1 more source

The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration. [PDF]

PLoS ONE, 2011
CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function ...
Silvia Moncini, Alessandro Salvi, Paola Zuccotti, Gabriella Viero, Alessandro Quattrone, Sergio Barlati, Giuseppina De Petro, Marco Venturin, Paola Riva   +8 more
doaj   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Sox6 associates with Cdk5/p35.

, 2014
(A) Sox6 was immunoprecipitated (IP) from postnatal day 1 (PN1) rat brain lysate and subjected to Western blotting using Sox6, Cdk5 and p35 antibodies. (B) Co-IP of Cdk5 and Sox6.
Howard Jaffe (540994), Elias Utreras (5658445), Ashok B. Kulkarni (467110), Parvathi Rudrabhatla (541984)   +3 more
core   +1 more source

Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. [PDF]

PLoS ONE, 2014
Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.
Kazuya Tanabe, Hiroyuki Yamazaki, Yutaka Inaguma, Akiko Asada, Taeko Kimura, Junya Takahashi, Masato Taoka, Toshio Ohshima, Teiichi Furuichi, Toshiaki Isobe, Koh-ichi Nagata, Tomoaki Shirao, Shin-ichi Hisanaga   +12 more
doaj   +1 more source

What do public contributors with lived experience know and think about open research? ‘Nobody should look at results and think “how did they arrive at that?”’

Journal of Neuropsychology, EarlyView.
Abstract Involving people with lived experience in research (patient and public involvement or co‐production) is one principle of open research (transparent research practices). Involvement of experts by experience helps ensure that clinical and health research is relevant, ethical and accessible.
Ellen Poliakoff, Hayley Shepherd, Ying Bai, Jade Pickering, Anne Ferrett, Peter Baimbridge, Graham Hanks, Emma Gowen   +7 more
wiley   +1 more source