Results 71 to 80 of about 27,357 (213)

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Neurosignals, 2012
Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y. Ip   +4 more
doaj   +1 more source

What do public contributors with lived experience know and think about open research? ‘Nobody should look at results and think “how did they arrive at that?”’

Journal of Neuropsychology, EarlyView.
Abstract Involving people with lived experience in research (patient and public involvement or co‐production) is one principle of open research (transparent research practices). Involvement of experts by experience helps ensure that clinical and health research is relevant, ethical and accessible.
Ellen Poliakoff, Hayley Shepherd, Ying Bai, Jade Pickering, Anne Ferrett, Peter Baimbridge, Graham Hanks, Emma Gowen   +7 more
wiley   +1 more source

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Frontiers in Immunology
BackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang, Yaxiong Li, Li Zhao, Bin Liu, Zhibin Cai, Peng Zhang, Peng Li, Xuezhen Gao, Yong Zhan   +8 more
doaj   +1 more source

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Disease Models & Mechanisms, 2018
Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age.
Joshua Spurrier, Arvind Kumar Shukla, Kristina McLinden, Kory Johnson, Edward Giniger   +4 more
doaj   +1 more source

The Caspase-8 Homolog Dredd Cleaves Imd and Relish but Is Not Inhibited by p35*

Journal of Biological Chemistry, 2014
Background: During the Drosophila immune response, both Imd and Relish are cleaved in a manner dependent on the caspase-8 homolog Dredd. Results: Dredd cleaves Imd and Relish, but not the caspase inhibitor p35, without interdomain autoprocessing ...
Chan-Hee Kim, Donggi Paik, Florentina Rus, N. Silverman   +3 more
semanticscholar   +1 more source

Parents’ and Caregivers’ Experiences of Procedural Holding and Restraint: ‘We Want To Be Their Safe Place and Not Associated With Medical Trauma’: A Qualitative Descriptive Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To explore parent/caregivers’ perceptions of procedures in which their child was held still and the reported impact of these experiences on both the child and parent. Design Qualitative descriptive study using an online survey. Methods Three research teams (United Kingdom (UK), New Zealand (NZ), and Australia) administered a qualitative ...
Lucy Bray, Julie Blamires, Michael Neufeld, Jenny O‘neill, Blake Peck, Erin Hargreaves, Sharon Kinney, Sage Hay   +7 more
wiley   +1 more source

Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation

Nature Cell Biology, 2014
Energy sensing by the AMP-activated protein kinase (AMPK) is of fundamental importance in cell biology. In the pancreatic β-cell, AMPK is a central regulator of insulin secretion.
Jun-ichi Sakamaki, Accalia Fu, Courtney Reeks, S. Baird, Chantal Depatie, Mufida Al Azzabi, N. Bardeesy, A. Gingras, S. Yee, R. Screaton   +9 more
semanticscholar   +1 more source

Cdk5 Regulates the Organization of Nestin and Its Association with p35 [PDF]

Molecular and Cellular Biology, 2003
The intermediate filament protein nestin is characterized by its specific expression during the development of neuronal and myogenic tissues. We identify nestin as a novel in vivo target for cdk5 and p35 kinase, a critical signaling determinant in development.
Cecilia M, Sahlgren, Andrey, Mikhailov, Samuli, Vaittinen, Hanna-Mari, Pallari, Hannu, Kalimo, Harish C, Pant, John E, Eriksson   +6 more
openaire   +2 more sources

Staying in the Unknown: Avoidance of Genetic Testing in Families With Hereditary Cancer Syndromes—A Qualitative Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aims To explore the experiences and challenges associated with genetic testing decisions among untested individuals from hereditary breast and ovarian cancer (HBOC) or Lynch syndrome (LS) families. Design Qualitative descriptive study. Methods Semi‐structured telephone interviews were conducted between 2022 and 2024 with 56 untested at‐risk ...
Ronit G. Tsemach, Elizabeth E. Half, Hagit Baris‐Feldman, Anastasia Weis, Sharon Simchoni, Sue Kim, Maria C. Katapodi, Sivia Barnoy, Efrat Dagan   +8 more
wiley   +1 more source

Cdk5/p35 functions as a crucial regulator of spatial learning and memory

Molecular Brain, 2014
BackgroundCyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation.
Tomohide Mishiba, Mika Tanaka, Naoki Mita, Xiaojuan He, Kodai Sasamoto, S. Itohara, T. Ohshima   +6 more
semanticscholar   +1 more source