Results 71 to 80 of about 25,694 (216)

p35 Is Required for CDK5 Activation in Cellular Senescence [PDF]

Journal of Biological Chemistry, 2010
The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence. Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in senescence-like changes. The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the best known function of which is in neuronal development ...
Daqin, Mao, Philip W, Hinds
openaire   +2 more sources

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Neurosignals, 2012
Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y. Ip   +4 more
doaj   +1 more source

Effects of gastric acid on surface roughness, microhardness, fracture strength, and color change of dental ceramics: A systematic review of in vitro studies

Journal of Prosthodontics, EarlyView.
Abstract Purpose This systematic review evaluated the effects of simulated gastric acid (SGA) on surface and mechanical properties of dental ceramics to answer the research question: Does immersion in SGA alter the surface roughness, microhardness, fracture strength, and color of dental ceramics?
Geany Ferreira Rodrigues, Isaac Augusto Dantas Nogueira, Nicole Escórcio de Meneses, Ana Letícia Daniel Fontenele, Francisbênia Alves Silvestre, Ana Carolina Lima Moreira, Lívia Maria Sales Pinto Fiamengui, Karina Matthes de Freitas Pontes, Raniel Fernandes Peixoto   +8 more
wiley   +1 more source

t(1;14)(p35;q32) LAPTM5/IGH [PDF]

, 2020
Review on t(1;14)(p35;q32), with data on clinics, and the genes ...
Huret, Jean Loup
core   +1 more source

Simultaneous reduction of dietary protein and daily feeding rate in biofloc system: Effect on water quality, growth, digestive and antioxidant capacity, immune response, and resistance to Aeromonas hydrophila in common carp

Aquaculture Reports
This experiment evaluated the impacts of simultaneous reduction of dietary protein and daily feeding rate in a biofloc system on performance of common carp, Cyprinus carpio.
Hossein Adineh, Mahdi Naderi, Mohammad Amini Chermahini, Golbahar Zeitounli, Mohammad Meysam Salahi Ardekani   +4 more
doaj   +1 more source

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Disease Models & Mechanisms, 2018
Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age.
Joshua Spurrier, Arvind Kumar Shukla, Kristina McLinden, Kory Johnson, Edward Giniger   +4 more
doaj   +1 more source

Endogenous RALF peptide function is required for powdery mildew host colonization

New Phytologist, EarlyView.
Model of RALF‐FER‐dependent effects on powdery mildew sporulation. Summary The receptor kinase FERONIA (FER) is a susceptibility factor for biotrophic powdery mildew fungal pathogens in Arabidopsis thaliana, but the underlying molecular mechanisms remain largely unknown. FER is required for the perception of endogenous RAPID ALKALINIZATION FACTOR (RALF)
Henriette Leicher, Sebastian D. Schade, Jan W. Huebbers, Kristina S. Munzert‐Eberlein, Genc Haljiti, David Biermann, Athanasios Makris, Xiaoxuan Zhu, Yashank Chauhan, Christina Ludwig, Marion C. Müller, Toshinori Kinoshita, Timo Engelsdorf, Julien Gronnier, Martina K. Ried‐Lasi, Aurélien Boisson‐Dernier, Ralph Hückelhoven, Martin Stegmann   +17 more
wiley   +1 more source

The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35

Molecular Biology of the Cell, 2016
In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, which inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in Alzheimer’s disease (AD) model mice, the peptide specifically inhibits the Cdk5/p25 complex and not the ...
Amin, Niranjana D., Zheng, Yali, BK, Binukumar, Shukla, Varsha, Skuntz, Susan, Grant, Philip, Steiner, Joseph, Bhaskar, Manju, Pant, Harish C.   +8 more
openaire   +2 more sources

Activation of CDK5 by p35 or its mutants.

, 2015
(A) The binding of p35 to CDK5. Wild-type p35 (wt), p35 A108V:L178L (A108V), or p35 L302I was coexpressed with CDK5 in COS-7 cells. CDK5-p35 was immunoprecipitated from the cell lysates using the anti-CDK5 antibody. Quantification is shown at the bottom (
Shunsuke Takada (338027), Taro Saito (358910), Karl Peter Giese (814072), Keiko Mizuno (814071), Akiko Asada (538347), Shin-ichi Hisanaga (177755)   +5 more
core   +1 more source

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Frontiers in Immunology
BackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang, Yaxiong Li, Li Zhao, Bin Liu, Zhibin Cai, Peng Zhang, Peng Li, Xuezhen Gao, Yong Zhan   +8 more
doaj   +1 more source