Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock [PDF]
eLife, 2019 Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases.
Andrea Brenna +9 more
doaj +7 more sources
Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy [PDF]
Journal of Diabetes Investigation, 2022 Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano +6 more
doaj +2 more sources
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons [PDF]
Molecular Pain, 2023 Chronic pain is one of the most devastating and unpleasant conditions, associated with many pathological states. Tissue or nerve injuries induce extensive neurobiological plasticity in nociceptive neurons, which leads to chronic pain.
Manindra Nath Tiwari +7 more
doaj +2 more sources
A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999–2025) [PDF]
Frontiers in Bioengineering and BiotechnologyCyclin-dependent kinase 5 (CDK5) is a critical regulator of neuronal development and function, whose hyperactivation exacerbates neurodegenerative disorders and certain cancers.
Varvara M. Derzhavina +2 more
doaj +2 more sources
Regulation of Sox6 by cyclin dependent kinase 5 in brain. [PDF]
PLoS ONE, 2014 Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration.
Parvathi Rudrabhatla +3 more
doaj +5 more sources
Targeting the cyclin-dependent kinase 5 in metastatic melanoma. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Melanomas are notorious due to their propensity to form lethal metastases. Currently, no treatments are available to stop the metastatic spread. We observed that in malignant melanomas, a protein called the cyclin-dependent kinase 5 (CDK5) is essential for melanoma metastasis.
Sharma S +17 more
europepmc +4 more sources
The role of cyclin-dependent kinase 5 in neuropathic pain. [PDF]
Pain, 2020 Abstract The chronification of pain can be attributed to changes in membrane receptors and channels underlying neuronal plasticity and signal transduction largely within nociceptive neurons that initiate and maintain pathological pain states.
Gomez K +6 more
europepmc +4 more sources
Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
PLoS ONE, 2009 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli +7 more
doaj +3 more sources
Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice [PDF]
Frontiers in Molecular Neuroscience, 2018 Cyclin-dependent kinase 5 (CDK5) is abundantly expressed in post-mitotic cells including neurons. It is involved in multiple cellular events, such as cytoskeletal dynamics, signaling cascades, gene expression, and cell survival, et al.
Xiaoyan Zhai +7 more
doaj +2 more sources
Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma [PDF]
BMC Cancer, 2019 Background This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.
Liangsong Zhu +4 more
doaj +2 more sources