Results 1 to 10 of about 14,364,653 (143)

CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2019
Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.
Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin, Jie Zhang   +10 more
doaj   +1 more source

Cdk5 Phosphorylates a Component of the HDAC Complex and Regulates Histone Acetylation during Neuronal Cell Death

Neurosignals, 2012
Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y. Ip   +4 more
doaj   +1 more source

Novel terbium-sensitizing peptide substrates for cyclin-dependent kinase 5 (CDK5) and their demonstration in luminescence kinase assays [PDF]

RSC Chemical Biology
Novel time-resolved terbium luminescence assays were developed for CDK5 and CDK2 by designing synthetic substrates which incorporate phospho-inducible terbium sensitizing motifs with kinase substrate consensus sequences.
Jason L. Heier, Dylan J. Boselli, Laurie L. Parker   +2 more
doaj   +1 more source

Loss of cyclin‐dependent kinase‐like 5 results in susceptibility to audiogenic seizures in mice

Epilepsia Open
CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early‐onset, treatment‐resistant epilepsy. Mice lacking CDKL5 display several clinically relevant phenotypes, but spontaneous seizures are not consistently ...
Jordan Higgins, Samuel Egan, Bilal El‐Mansoury, David C. Henshall, Omar Mamad   +4 more
doaj   +1 more source

CDK5 affects the resistance of lung cancer to radiotherapy by altering the tumor microenvironment

Journal of Radiation Research and Applied Sciences
This article aims to explore the impact of cyclin-dependent kinase 5 (CDK5) on the tumor microenvironment and its influence on radiotherapy resistance in lung cancer through bioinformatics analysis.
Hua-Fei Chen, Chun-Wei Xu, Wen-Xian Wang, Puen Chen, Xiao-Feng Li, Gang Lan, Zhan-Qiang Zhai, You-Cai Zhu, Kai-Qi Du, Li-Chao Huang   +9 more
doaj   +1 more source

CDK5: Key Regulator of Apoptosis and Cell Survival

Biomedicines, 2019
The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator p35,
Rabih Roufayel, Nimer Murshid
doaj   +1 more source

Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma

BMC Cancer, 2019
Background This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.
Liangsong Zhu, Rong Ding, Jianping Zhang, Jin Zhang, Zongming Lin   +4 more
doaj   +1 more source

The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antileukemic potential of isoindigos make them desired candidates for understanding their mechanism of action. We have recently synthesized a novel group of pyridone-annelated isoindigos and identified the derivative 5'-Cl that is ...
Ayman M. Saleh, Ahmad Aljada, Mustafa M. El-Abadelah, Mutasem O. Taha, Salim S. Sabri, Jalal A. Zahra, Mohammad Azhar Aziz   +6 more
doaj   +1 more source

Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus

International Journal of Endocrinology, 2011
Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+ channels (KATP) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are
Danish Ahmed, Manju Sharma
doaj   +1 more source

Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis

Frontiers in Pharmacology
Background and aimBenign prostatic hyperplasia (BPH) involves androgen-driven proliferation with reduced apoptosis. Current 5α-reductase inhibitors can cause adverse effects, motivating safer options.
Jun-Hui Song, Daeun Lee, Byungdoo Hwang, Seon-Kyung Hwang, Sumin Choo, Hyeon Ji Jeong, Hoon Kim, Byungyoon Cha, Seok-Joong Yun, Yung Hyun Choi, Wun-Jae Kim, Wun-Jae Kim, Sung-Kwon Moon   +12 more
doaj   +1 more source