Results 11 to 20 of about 185,382 (296)

Cyclin-dependent Kinase 5 Promotes Insulin Exocytosis [PDF]

Journal of Biological Chemistry, 2001
Cyclin-dependent kinase 5 (Cdk5) is widely expressed although kinase activity has been described preferentially in neuronal systems. Cdk5 has an impact on actin polymerization during neuronal migration and neurite outgrowth and deregulation of the kinase has been implicated in the promotion of neurodegeneration.
L, Lilja, S N, Yang, D L, Webb, L, Juntti-Berggren, P O, Berggren, C, Bark   +5 more
openaire   +3 more sources

Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association. [PDF]

Virulence, 2023
   As a member of the pattern recognition receptors (PRRs) involving in the innate immune system, Toll-like receptors (TLRs) can sense a wide range of microbial pathogens and combat infections by producing antimicrobial products, inflammatory cytokines ...
Ren JP, Cong HL, Gao LJ, Jiang DF, Li XT, Wang Y, Wang JQ, Tang TS.   +7 more
europepmc   +3 more sources

Turkish cases of early infantile epileptic encephalopathy: two novel mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene

The Turkish Journal of Pediatrics, 2015
Cyclin-dependent kinase-like 5 gene-related epileptic encephalopathy is gradually becoming better known in child neurology practice. The related gene mutations cause early infantile epileptic encephalopathy characterized by intractable epilepsy ...
Sarenur Gökben, Gül Serdaroğlu, Sanem Yılmaz, Thierry Bienvenu, Serdar Ceylaner   +4 more
doaj   +3 more sources

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and ...
Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan, James A. Bibb, James A. Bibb, James A. Bibb   +11 more
doaj   +1 more source

Cyclin‐dependent kinase‐5 in neurodegeneration [PDF]

Journal of Neurochemistry, 2004
AbstractCyclin‐dependent kinase‐5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be involved in the pathogenesis of several neurodegenerative disorders.
Shirley B, Shelton, Gail V W, Johnson
openaire   +3 more sources

Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice

Biomedicines, 2022
Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-induced
Benjamin Thilo Krüger, Lena Steppe, Sabine Vettorazzi, Melanie Haffner-Luntzer, Sooyeon Lee, Ann-Kristin Dorn, Anita Ignatius, Jan Tuckermann, Mubashir Ahmad   +8 more
doaj   +1 more source

Cyclin-Dependent Kinase 5 Is Required for Associative Learning [PDF]

The Journal of Neuroscience, 2002
Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress.
Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., Radulovic, J.   +4 more
openaire   +4 more sources

Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5). [PDF]

PLoS ONE, 2015
Low voltage-activated (LVA) T-type Ca2+ channels activate in response to subthreshold membrane depolarizations and therefore represent an important source of Ca2+ influx near the resting membrane potential.
Aida Calderón-Rivera, Alejandro Sandoval, Ricardo González-Ramírez, Christian González-Billault, Ricardo Felix   +4 more
doaj   +1 more source

Investigation of the effect of 5-Aza-2'-deoxycytidine in comparison to and in combination with trichostatin a on p16INK4a, p14ARF, p15INK4b gene expression, cell growth inhibition and apoptosis induction in colon cancer Caco-2 cell line

International Journal of Preventive Medicine, 2021
Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei, Fraidoon Kavoosi, Vahid Ghasemzadeh   +2 more
doaj   +1 more source

Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy

Biomédica: revista del Instituto Nacional de Salud, 2018
Introduction: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is ...
Juan Ignacio Muñoz-Manco, Johanna Andrea Gutiérrez-Vargas, Gloria Patricia Cardona-Gómez   +2 more
doaj   +1 more source