Results 31 to 40 of about 165,369 (255)
Mechanistic insight of cyclin-dependent kinase 5 in modulating lung cancer growth
Chinese Journal of Physiology, 2019 Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase ...
G. M. Shazzad Hossain Prince +3 more
doaj +1 more source
Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. [PDF]
PLoS ONE, 2014 Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase which plays a key role in neuronal migration, neurite outgrowth, and spine formation during brain development.
Kazuya Tanabe +12 more
doaj +1 more source
Cyclin C: The Story of a Non-Cycling Cyclin
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek +8 more
doaj +1 more source
The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer
CellsCyclin-dependent kinase 5 (Cdk5) is an atypical serine/threonine kinase distinct from classical cell cycle regulators. Its activity is highest in the nervous system and essential for development, but its functions in other tissues, particularly in cancer,
Yoshiaki V. Nishimura, Takeshi Kawauchi
doaj +1 more source
Cyclin-Dependent Kinase 5 in Amyotrophic Lateral Sclerosis
Neurosignals, 2003 Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering ...
Minh Dang, Nguyen, Jean-Pierre, Julien
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Cyclin-dependent Kinase 5: Novel role of gene variants identified in ADHD
Scientific Reports, 2017 Cortical neuronal migration and formation of filamentous actin cytoskeleton, needed for development, normal cell growth and differentiation, are regulated by the cyclin-dependent kinase 5 (Cdk5).
Subhamita Maitra +3 more
doaj +1 more source
Crosstalk between Cdk5 and GSK3β: Implications for Alzheimer's Disease
Frontiers in Molecular Neuroscience, 2009 GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration.
Olivia Engmann, Karl P Giese
doaj +1 more source
Cell Reports, 2021 Summary: HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear.
Qingqing Chai +13 more
doaj +1 more source
Activation of Cyclin‐Dependent Kinase 5 Is a Consequence of Cell Death [PDF]
BioMed Research International, 2009 Cyclin‐dependent kinase 5 (Cdk5) is similar to other Cdks but is activated during cell differentiation and cell death rather than cell division. Since activation of Cdk5 has been reported in many situations leading to cell death, we attempted to determine if it was required for any form of cell death.
Ye, Yixia +4 more
openaire +2 more sources