Results 21 to 30 of about 165,369 (255)

Activation of Cyclin-Dependent Kinase 5 Mediates Orofacial Mechanical Hyperalgesia

Molecular Pain, 2013
Background Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerative disorders.
Michaela Prochazkova, Anita Terse, Niranjana D Amin, Bradford Hall, Elias Utreras, Harish C Pant, Ashok B Kulkami   +6 more
doaj   +1 more source

Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids

Neurobiology of Disease, 2023
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in ...
Marta Barrera-Conde, Emma Veza-Estévez, Maria Gomis-Gonzalez, Jordi Garcia-Quintana, Amira Trabsa, Laura Martínez-Sadurní, Mitona Pujades, Víctor Perez, Rafael de la Torre, Daniel Bergé, Patricia Robledo   +10 more
doaj   +1 more source

Regulation of NMDA receptors by cyclin-dependent kinase-5 [PDF]

Proceedings of the National Academy of Sciences, 2001
Members of the N -methyl- d -aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system.
B S, Li, M K, Sun, L, Zhang, S, Takahashi, W, Ma, L, Vinade, A B, Kulkarni, R O, Brady, H C, Pant   +8 more
openaire   +2 more sources

A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]

Open Biology, 2020
The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
doaj   +1 more source

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells

Tumor Biology, 2018
Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation.
Girolamo Spagnoletti, Valeria Li Bergolis, Annamaria Piscazzi, Francesca Giannelli, Valentina Condelli, Lorenza Sisinni, Giuseppe Bove, Giovanni Storto, Matteo Landriscina   +8 more
doaj   +1 more source

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

Frontiers in Aging Neuroscience, 2018
Parkinson’s disease (PD) is one of the most affected neurodegenerative diseases in the world. Deregulation of cyclin-dependent kinase 5 (Cdk5) is believed to play an important role in neurodegenerative diseases including PD.
Rongni He, Rongni He, Wei Huang, Yaowei Huang, Miaojing Xu, Pingping Song, Yinwei Huang, Huifang Xie, Yafang Hu   +8 more
doaj   +1 more source

Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5 [PDF]

Biochemical Journal, 2004
Doublecortin (DCX) is a 40 kDa microtubule-associated protein required for normal neural migration and cortical layering during development. Mutations in the human DCX gene cause a disruption of cortical neuronal migration. Defects in cdk5 (cyclin-dependent kinase 5) also cause defects in neural migration and cortical layering.
Mark E, Graham, Patricia, Ruma-Haynes, Amanda G, Capes-Davis, Joanne M, Dunn, Timothy C, Tan, Valentina A, Valova, Phillip J, Robinson, Peter L, Jeffrey   +7 more
openaire   +2 more sources

Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells

Stem Cells International, 2016
The potential use of stem cells as therapeutics in disease has gained momentum over the last few years and recently phase-I clinical trials have shown favourable results in treatment of a small cohort of acute stroke patients.
Wen-Hui Fang, Shant Kumar, Garry McDowell, David Smith, Jurek Krupinski, Peter Olah, Raid Saleem Al-Baradie, Mohammad Othman Al-Rukban, Eugene Bogdan Petcu, Mark Slevin   +9 more
doaj   +1 more source

Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.

Frontiers in Cellular Neuroscience, 2013
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura, Ryoma eMorigaki, Jiro eKasahara, Hironori eYokoyama, Akie eTanabe, Shinya eOkita, Hidetaka eKoizumi, Shinji eNagahiro, Ryuji eKaji, Satoshi eGoto   +9 more
doaj   +1 more source

Cyclin-dependent Kinase 5 Promotes Insulin Exocytosis [PDF]

Journal of Biological Chemistry, 2001
Cyclin-dependent kinase 5 (Cdk5) is widely expressed although kinase activity has been described preferentially in neuronal systems. Cdk5 has an impact on actin polymerization during neuronal migration and neurite outgrowth and deregulation of the kinase has been implicated in the promotion of neurodegeneration.
L, Lilja, S N, Yang, D L, Webb, L, Juntti-Berggren, P O, Berggren, C, Bark   +5 more
openaire   +2 more sources