Results 41 to 50 of about 25,694 (216)

CDK5: an oncogene or an anti-oncogene: location location location

Molecular Cancer, 2023
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
doaj   +1 more source

Internal Marketing of Sustainability: Nonmanagerial Employees' Perspectives in the Hospitality Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainable business practices are widely promoted in hospitality, yet a persistent gap persists between sustainability strategies and their implementation in daily operations. This study focuses on the sustainability strategy–implementation gap by examining how nonmanagerial employees, responsible for operational delivery, perceive and ...
Zivai Machaka Mare, Humeyra Dogru Dastan
wiley   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

TrkB Interacted with Cdk5 and p35

, 2013
(A) TrkA, TrkB, and TrkC all contain proline-directed serine/threonine residues in the juxtamembrane region of the receptors (indicated by arrows). Nonetheless, only TrkB and TrkC contain Cdk5 consensus sites S/TPXK/H/R. (B) Cell lysates from
Zelda H Cheung (69052), Yu Chen (29959), Wing Hong Chin (69053), Nancy Y Ip (69055), Yu Pong Ng (69054)   +4 more
core   +1 more source

Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.

PLoS ONE, 2014
The testis is an organ with immune privilege. The comprehensive blood-testis barrier formed by Sertoli cells protects autoimmunogenic spermatozoa and spermatids from attack by the body's immune system. The interleukin (IL)-6/IL-12 family cytokines IL-12 (
Hayato Terayama, Takayuki Yoshimoto, Shuichi Hirai, Munekazu Naito, Ning Qu, Naoyuki Hatayama, Shogo Hayashi, Kana Mitobe, Jun-Ichi Furusawa, Izuru Mizoguchi, Takeshi Kezuka, Hiroshi Goto, Kaori Suyama, Hiroshi Moriyama, Kou Sakabe, Masahiro Itoh   +15 more
doaj   +1 more source

Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity. [PDF]

PLoS ONE, 2013
Cytokine immunogene therapy is a promising strategy for cancer treatment. Interleukin (IL)-12 boosts potent antitumor immunity by inducing T helper 1 cell differentiation and stimulating cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Il-Kyu Choi, Yan Li, Eonju Oh, Jaesung Kim, Chae-Ok Yun   +4 more
doaj   +1 more source

BmNPV p35 Reduces the Accumulation of Virus-Derived siRNAs and Hinders the Function of siRNAs to Facilitate Viral Infection

Frontiers in Immunology, 2022
Antiviral immunity involves various mechanisms and responses, including the RNA interference (RNAi) pathway. During long-term coevolution, viruses have gained the ability to evade this defense by encoding viral suppressors of RNAi (VSRs). It was reported
Shudi Zhao, Shudi Zhao, Guanping Chen, Guanping Chen, Xiangshuo Kong, Xiangshuo Kong, Nan Chen, Nan Chen, Xiaofeng Wu, Xiaofeng Wu   +9 more
doaj   +1 more source

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Interaction between p35 and EBI3.

, 2014
(A) HEK293 cells were transiently transfected with either p35 or EBI3. Cells were lysed, and lysates were mixed. To check for unspecific binding of p35 to the beads, lysates of p35-transfected cells without EBI were used as control (Ctrl).
Jens M. Moll (540876), Jürgen Scheller (53995), Christoph Garbers (635127), Juliane Lokau (635123), Melanie Grusdat (635124), Svenja Plöhn (635126), Philipp A. Lang (36068), Stefan Rose-John (53994), Joachim Grötzinger (141796), Samadhi Aparicio-Siegmund (635122), Jutta Schröder (635125)   +10 more
core   +1 more source

Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy

Journal of Diabetes Investigation, 2022
Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano, Kazuhiko Namekata, Masanori Niki, Kentaro Semba, Fumiko Murao, Takayuki Harada, Yoshinori Mitamura   +6 more
doaj   +1 more source