Results 81 to 90 of about 17,484 (210)

Mechanistic insight of cyclin-dependent kinase 5 in modulating lung cancer growth

Chinese Journal of Physiology, 2019
Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase ...
G. M. Shazzad Hossain Prince, Tsung-Ying Yang, Ho Lin, Mei-Chih Chen   +3 more
doaj   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley, Tatsuya Sueyoshi, Sivapriya Ramamoorthy, Viktoriya D. Nikolova, David R. Goulding, Jianying Li, Manas K. Ray, Sheryl S. Moy, John A. Cidlowski   +8 more
wiley   +1 more source

Cdk5 phosphorylates Grin1 at Ser369.

, 2014
A) Grin1 alignment showing Ser369 and Ser691 sequence as Cdk5 motifs. The shaded boxes show conserved amino acids, bold amino acid is the phosphorylation site. B) Detection of Grin1 in rat B104 and mouse N2A neuroblastoma cells and mouse brain.
Howard Jaffe (540994), Erick Contreras-Vallejos (540989), Michaela Prochazkova (540992), Cristina Arruti (407435), Elías Utreras (540990), Daniel A. Bórquez (540991), Andrea Toledo (407433), Anita Terse (540993), Christian González-Billault (108996), Harish C. Pant (454843), Ashok B. Kulkarni (467110)   +10 more
core   +1 more source

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.

PLoS Biology, 2007
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of ...
Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip   +4 more
doaj   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

TrkB Interacted with Cdk5 and p35

, 2013
(A) TrkA, TrkB, and TrkC all contain proline-directed serine/threonine residues in the juxtamembrane region of the receptors (indicated by arrows). Nonetheless, only TrkB and TrkC contain Cdk5 consensus sites S/TPXK/H/R. (B) Cell lysates from
Zelda H Cheung (69052), Yu Chen (29959), Wing Hong Chin (69053), Nancy Y Ip (69055), Yu Pong Ng (69054)   +4 more
core   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Binding of AATYK1A to Cdk5/p35.

, 2013
(A) Coimmunoprecipitation of Cdk5/p35 with AATYK1A in HEK293 cells. AATYK1A-Flag was coexpressed with p35 and/or Cdk5 in HEK293 cells and immunoprecipitated from cell lysates using the anti-Flag antibody.
Koji Tsutsumi (365453), Shin-ichi Hisanaga (177755), Tetsuya Takano (365454), Ryo Endo (365455), Mitsunori Fukuda (87862), Mineko Tomomura (365456), Toshio Ohshima (154229)   +6 more
core   +1 more source

Biphasic Memory Impairment and Recovery After Sevoflurane Exposure Are Associated With Time‐Dependent Hippocampal α5‐GABAAR Remodeling

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our study reveals that the reversible changes in memory impairment and recovery following sevoflurane with dynamic changes of expression and distribution of α5‐GABAAR. Memory impairment is associated with the upregulation of α5‐GABAAR expression and postsynaptic distribution on day 2 after sevoflurane exposure.
Sixuan Wang, Lu Chen, Shengran Wang, Chen Zhang, Mengxue Zhang, Zhun Wang, Jinpeng Dong, Qiangwei Liu, Zhonglan Dong, Xiaokun Wang, Ying Dong, Yuan Luo, Yongan Wang, Yiqing Yin   +13 more
wiley   +1 more source

Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain

, 1996
Neuronal cdc2-like kinase (Nclk) purified from bovine brain is a heterodimer of Cdk5 and an essential 25-kDa regulatory subunit (Lew, J., and Wang, J. H. (1995) Trends Biochem. Sci. 20, 33-37). The regulatory subunit is an N-terminal truncated derivative
Wang, Jerry H., Lee, Ki Young, Tang, Damu, Rosales, Jesusa L.   +3 more
core   +1 more source