Results 91 to 100 of about 17,484 (210)
Peripheral and orofacial pain sensation is unaffected by the loss of p39
Molecular Pain, 2017 Cdk5 is a key neuronal kinase necessary for proper brain development, which has recently been implicated in modulating nociception. Conditional deletion of Cdk5 in pain-sensing neurons attenuates pain responses to heat in both the periphery and orofacial
Michaela Prochazkova +9 more
doaj +1 more source
eLife, 2017 Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood.
Nilay Nandi +3 more
doaj +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.In small cell lung cancer, high tumor ICOSLG expression drives a microenvironment enriched with immunosuppressive T cells and M2 macrophages. Conversely, ICOSLG low tumors promote CD8+ T cell infiltration. Clinically, high ICOSLG levels predict poor response to immune checkpoint inhibitors and worse survival, whereas low ICOSLG expression indicates ...
Qiji Guo +9 more
wiley +1 more source
Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein
Cell Reports, 2015 Axonal transport is essential for neuronal function, and defects in transport are associated with multiple neurodegenerative diseases. Aberrant cyclin-dependent kinase 5 (CDK5) activity, driven by the stress-induced activator p25, also is observed in ...
Eva Klinman, Erika L.F. Holzbaur
doaj +1 more source
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
CDK5 interacts with STK3 [PDF]
, 2023 The Hippo-YAP/TAZ pathway is the most prevalent evolutionary conserved pathway from Drosophila to mammals and plays a key role in controlling organ size, cell growth, self-renewal, and tissue homeostasis.
Passi, Mehak
core
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators.
, 1996 While cyclin-dependent kinase 5 (Cdk5) is widely distributed in mammalian tissues and in cultured cell lines, Cdk5-associated kinase activity has been demonstrated only in mammalian brains.
Tang, D., Wang, J. H.
core
Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer
MedComm, Volume 7, Issue 6, June 2026.This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang +11 more
wiley +1 more source