Results 111 to 120 of about 17,484 (210)

Activation of Cyclin-Dependent Kinase 5 Mediates Orofacial Mechanical Hyperalgesia

Molecular Pain, 2013
Background Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerative disorders.
Michaela Prochazkova, Anita Terse, Niranjana D Amin, Bradford Hall, Elias Utreras, Harish C Pant, Ashok B Kulkami   +6 more
doaj   +1 more source

Cdk5 is essential for synaptic vesicle endocytosis [PDF]

, 2003
Synaptic vesicle endocytosis (SVE) is triggered by calcineurin-mediated dephosphorylation of the dephosphin proteins. SVE is maintained by the subsequent rephosphorylation of the dephosphins by unidentified protein kinases.
Boris Sarcevic, Ross A. Boadle, Boadle, Ross A, Sarcevic, Boris, McClure, Sonya J, Valentina A. Valova, Phillip J. Robinson, Robinson, Phillip J, Graham, Mark E, Orla J. Jupp, Timothy C. Tan, Malladi, Chandra S, Cousin, Michael A, Michael A. Cousin, Mark E. Graham, Martin R. Larsen, Chandra S. Malladi, Hansra, Gurdip, Valova, Valentina A, Larsen, Martin R, Tan, Timothy C, Berven, Leise A, Gurdip Hansra, Jupp, Orla J, Sonya J. McClure, Leise A. Berven, Larsen, Martin Røssel   +26 more
core   +1 more source

Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders

Molecular Neurodegeneration, 2011
Background Recent studies suggest that the pathogenic process in neurodegenerative disorders may disrupt mature neuronal circuitries and neurogenesis in the adult brain.
Rockenstein Edward, Achim Cristian L, Trejo-Morales Margarita, Dumaop Wilmar, Patrick Christina, Ruf Rebecca, Crews Leslie, Masliah Eliezer   +7 more
doaj   +1 more source

Cdk5: A Novel Role in Learning and Memory

Neurosignals, 2003
Learning and memory are processes by which organisms acquire, retain and retrieve information. They result in modifications of behavior in response to new or previously encountered stimuli thereby enabling adaptation to a permanently changing environment.
Fischer, A., Sananbenesi, F., Spiess, J., Radulovic, J.   +3 more
openaire   +3 more sources

Cdk5: Mediator of neuronal death and survival

, 2004
Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests.
Ip, Nancy Y., Ip, NY, Cheung, ZH, Cheung, Zelda H.   +3 more
core   +1 more source

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing

Scientific Reports
Cyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair.
Jingjing Wang, Lin Ji, Yingbo Gao, Jingyu Sun, Xiaobin Zhou, Yujia Ding, Zihan Zhou, Xiaofan Guo, Chao Liu, Yujie Wang, Qingfu Zhang, Zhenmu Lv, Dong Ma   +12 more
doaj   +1 more source

Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway

Journal of Inflammation Research, 2022
Zhen-Xiao Teng,1,* Xuan-Chen Zhou,2,* Run-Tong Xu,2 Fang-Yuan Zhu,2 Xin Bing,1 Na Guo,2 Lei Shi,2 Wen-Wen Qi,1 Cheng-Cheng Liu,3 Ming Xia1,2 1Department of Otolaryngology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong ...
Teng ZX, Zhou XC, Xu RT, Zhu FY, Bing X, Guo N, Shi L, Qi WW, Liu CC, Xia M   +9 more
doaj  

CDK5 knockdown virus infection results in reduced CDK5 expression and reduced numbers of phospho-gephyrin clusters in cultured hippocampal neurons.

, 2014
Hippocampal neurons (div14) were stained with anti-GFP antibodies to detect infected neurons (upper panel), with anti-CDK5 antibody to quantify CDK5 expression levels (middle panel) and with the phosphospecific anti-gephyrin mAb7a antibody (lower panel).
Jochen Kuhse (50843), Heba Kalbouneh (610559), Andrea Schlicksupp (50841), Joachim Kirsch (50842)   +3 more
core   +1 more source

Protein-protein interactions in Cdk5 regulation and function

, 2003
Cdk5 is a unique member of the cyclin-dependent kinase (Cdk) family of small protein kinases. In association with its neuron-specific activator p35 or p39, Cdk5 displays many regulatory properties distinct from other Cdks.
Qi, Robert Z., Qu, Dianbo, Lim, Anthony C.B.   +2 more
core   +1 more source

Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation

Neoplasia: An International Journal for Oncology Research
Aberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protein 2 (
Yingwei Huang, Qiqi Wang, Weiwei Zhou, Yawei Jiang, Kai He, Wei Huang, Yating Feng, Hong Wu, Lijuan Liu, Yue Pan, Yihua Huang, Zirui Chen, Wei Li, Yaowei Huang, Guanchuan Lin, Yulong Zhang, Yongyan Ren, Kaibiao Xu, Yanlin Yu, Yuping Peng, Xinghua Pan, Suyue Pan, Hailiang Hu, Yafang Hu   +23 more
doaj   +1 more source