Results 121 to 130 of about 17,484 (210)
, 2003 The phosphorylation status of amyloid precursor protein (APP) at Thr668 is suggested to play a critical role in the proteolytic cleavage of APP, which generates either soluble APPβ (sAPPβ) and β-amyloid peptide (Aβ), the major component of senile plaques
Binhui Ni +15 more
core +1 more source
Localization of CDK5 in the midbody and increased aneuploidy in CDK5-/-cells [PDF]
Cell Cycle, 2010 Ki-Young, Lee +4 more
openaire +2 more sources
, 2016 The Cdk5 siRNA and control siRNA were transfected into cultured podocyte (day 7), and roscovitine was used as a positive control to treat the cells.
Xiao-Hua Lu (454839) +11 more
core +1 more source
Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice
, 2010 Alzheimer's disease is a major cause of dementia for which treatments remain unsatisfactory. Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been hypothesized to contribute to the tau pathology.
Diego Piedrahita +22 more
core +1 more source
Investigation of the Roles of Cdk5 Protein in Poly Cystic Ovary Syndrome (WR2)
, 2014 多囊性卵巢症候群是一種好發於女性的常見疾病，通常被認為與雄性激素分泌異常有關，同時亦常伴隨著高胰島素血症的出現，此病徵可能導致病患日後出現如糖尿病、高血壓等慢性疾病，實為一個需要重視的疾病。另一方面，Cdk5蛋白在中樞神經系統發育及神經退化性疾病(如阿茲海默症)中扮演的角色於近年來被踴躍地討論。本實驗室自成立以來致力於探討Cdk5蛋白在人類各系統中的未知功能。已發表之研究成果顯示Cdk5蛋白對於髓質性甲狀腺癌細胞生長及癌化扮演重要角色；Cdk5蛋白於攝護腺癌細胞中可受到藥物過度活化而導致癌細胞凋亡 ...
林赫
core
Phosphorylation of AATYK1A at Ser34 by Cdk5.
, 2013 (A) In vitro phosphorylation of AATYK1A by Cdk5/p35. AATYK1A-Flag was expressed in HEK293 cells and isolated by immunoprecipitation using the anti-Flag antibody.
Koji Tsutsumi (365453) +6 more
core +1 more source
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC metastasis and ...
Huang, Xuan-Zhang +14 more
core +1 more source
The protein SET binds the neuronal Cdk5 activator p35(nck5a) and modulates Cdk5/p35(nck5a) activity
, 2002 The neuronal Cdk5 kinase is composed of the catalytic subunit Cdk5 and the activator protein p35(nck5a) or its isoform, p39(nck5ai). To identify novel p35(nck5a)- and p39(nck5ai)-binding proteins, fragments of p35(nck5a) and p39(nck5ai) were utilized in ...
Q Li (6964538) +6 more
core
A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999-2025). [PDF]
Front Bioeng BiotechnolDerzhavina VM +2 more
europepmc +1 more source