GSK-3 and Tau: A Key Duet in Alzheimer’s Disease [PDF]
Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a central position in cell metabolism and signaling, with important roles both ...
C Laura Sayas +2 more
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The Role of GSK-3 in Cancer Immunotherapy: GSK-3 Inhibitors as a New Frontier in Cancer Treatment [PDF]
Cells, 2020 The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified because of its key role in the regulation of glycogen synthesis. However, it is now well-established that GSK-3 performs critical functions in many cellular processes,
Antonina Azzolina +2 more
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GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder [PDF]
Frontiers in Molecular Neuroscience, 2012 The Wnt signaling pathway is critical for development of the mammalian central nervous system and regulates diverse processes throughout adulthood, including adult neurogenesis. Glycogen Synthase Kinase-3 (GSK-3) antagonizes the Wnt pathway and therefore
Peter S Klein, Klein Peter S
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Pathobiology and Therapeutic Relevance of GSK-3 in Chronic Hematological Malignancies [PDF]
Cells, 2022 Glycogen synthase kinase-3 (GSK-3) is an evolutionarily conserved, ubiquitously expressed, multifunctional serine/threonine protein kinase involved in the regulation of a variety of physiological processes.
Alberto M. Martelli +4 more
doaj +2 more sources
GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors [PDF]
Signal Transduction and Targeted TherapyAlthough the efficacy of immune checkpoint blockade (ICB) depends on coordinated activity across progenitor and terminal effector CD4⁺ and CD8⁺ T-cell compartments, the cell-intrinsic pathways that enable this cooperation remain incompletely defined ...
Bastien Moës +13 more
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GSK-3: Functional Insights from Cell Biology and Animal Models
Frontiers in Molecular Neuroscience, 2011 Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related proteins: GSK-3α and GSK-3β.
Oksana Kaidanovich-Beilin +1 more
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Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance [PDF]
Cells, 2022 Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases.
Manisha Gupte +5 more
doaj +2 more sources
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house ...
Paula Martínez de Iturrate +9 more
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Frontiers in Molecular Neuroscience, 2020 Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD).
Shanshan Ma +2 more
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New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis [PDF]
PeerJ, 2023 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions and is inactivated upon stimulation. In mammals, GSK-3 includes GSK-3 α and GSK-
Shenjin Lai +3 more
doaj +2 more sources