Results 41 to 50 of about 2,958 (235)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

open access: yesAdvanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander   +14 more
wiley   +1 more source

Synthesis of functionalized polyolefins in a new continuous bench‐scale reactor apparatus

open access: yesAIChE Journal, EarlyView.
Abstract In‐reactor functionalized polyolefins (FPOs), produced by molecular catalysts, are a new class of polymer materials with applications ranging from high performance adhesives to bitumen compatibilization. In this work, we disclose a procedure for the synthesis of FPOs in a new Continuous Bench‐scale Reactor Apparatus (COBRA).
Miloud Bouyahyi   +7 more
wiley   +1 more source

Por que as cobras têm cores diferentes ?

open access: yes, 2016
Ensino Fundamental Final::Ciências NaturaisÁudio produzido a partir do acervo radiofônico da Rádio UFMG Educativa - Programa Universidade das Crianças. Aborda sobre as cores das cobras,explica porque elas têm cores diferentes e a importância das cores na
Reis, Débora d'Ávila
core   +1 more source

Malaysian Cobra Venom: A Potential Source of Anti-Cancer Therapeutic Agents

open access: yesToxins, 2019
Cancer is a deadly disease and there is an urgent need for the development of effective and safe therapeutic agents to treat it. Snake venom is a complex mixture of bioactive proteins that represents an attractive source of novel and naturally-derived ...
Syafiq Asnawi Zainal Abidin   +3 more
doaj   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu   +7 more
wiley   +1 more source

As cobras no mundo, o mundo das cobras: narrativas de temor e reverência em Timor-Leste e um evento etnográfico [PDF]

open access: yes, 2022
Este texto analisa a representação e narrativas sobre as cobras em Timor-Leste, procurando descrever os sentimentos ambivalentes, o temor e a reverência, associados à sua presença e interação com os humanos, vivos e antepassados.This text analyses the ...
Sousa, Lúcio
core   +1 more source

Aspectos epidemiológicos dos acidentes ofídicos ocorridos no Estado de Roraima, Brasil, entre 1992 e 1998

open access: yesCadernos de Saúde Pública, 2000
O presente trabalho apresenta um estudo relativo a acidentes ofídicos ocorridos em oito municípios do Estado de Roraima entre 1992 e 1998. Trezentas e nove (309) fichas de registro de acidentes por serpentes peçonhentas foram descritas por localidade e ...
Nascimento Sebastião Pereira do
doaj  

Porcine kidney xenotransplantation: From primate models to clinical reality

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo   +3 more
wiley   +1 more source

Catching COBRAs [PDF]

open access: yes, 2013
With social media usage increasingly widespread and influential, companies face the challenge of inspiring and cultivating Consumers’ Online Brand-Related Activities (COBRAs). This dissertation argues that they can do so effectively only when they have a
Muntinga, D.G.
core  

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