Chronic stress is a global issue with detrimental effects on health and productivity, often leading individuals to adopt health‐related coping strategies. This study uses an adapted Job Demands–Resources model to examine how various job demands and resources impact perceived stress and, consequently, the use of legal, prescription, and illegal drugs ...
Sebastian Sattler +3 more
wiley +1 more source
Stimulant drug misuse in patients presenting to level 1 trauma centres: a retrospective analysis of 80 000 patients in Canada and the United States. [PDF]
Cristofaro C +5 more
europepmc +1 more source
The role of agomelatine in appetite regulation and body weight in rats
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz +3 more
wiley +1 more source
DUSP5 Downregulation in Nucleus Accumbens Core Correlates with Cocaine-Induced Maladaptive Synaptic Plasticity. [PDF]
Taborda-Bejarano JP +4 more
europepmc +1 more source
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin +8 more
wiley +1 more source
The Selective Bromodomain and Extra-Terminal Domain (BET) Inhibitor RVX-208 Reduces Cocaine-Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens. [PDF]
Sacko TJ +3 more
europepmc +1 more source
Limited effects of zolmitriptan maintenance on the pharmacodynamic profile of intravenous cocaine in humans. [PDF]
Stoops WW +6 more
europepmc +1 more source
ABSTRACT The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods. This review examines innovative nanomaterial‐based approaches for AMP detection, emphasizing their advantages over conventional analytical ...
Ilghar Zeinaly +5 more
wiley +1 more source
Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in male rats trained to self-administer cocaine or alcohol. [PDF]
Nedelescu H +11 more
europepmc +1 more source
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source

