Results 211 to 220 of about 47,059 (243)
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Neuropsychiatric effects of cocaine use disorders.
Journal of the National Medical Association, 2006Individuals who use cocaine report a variety of neuropsychiatric symptoms that are yet to be adequately targeted with treatment modalities. To address this problem requires an understanding of these symptoms and their neurobiological origins. Our paper reviewed the existing data on the neuropsychiatic implications of cocaine.
Charles U, Nnadi +3 more
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Vaccines for Treating Cocaine Use Disorders
2015The incidence and prevalence of cocaine use remain a significant public health issue. Annually, while it negatively impacts millions of individuals, contributes to thousands of deaths, and exerts a heavy burden on already stretched healthcare dollars and resources, to date, medications, or small-molecule approaches, to treat drug addictions have met ...
Coreen B. Domingo +2 more
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KOR agonists for the treatment and/or prevention of opioid use disorder and cocaine use disorder
Pharmacology Biochemistry and BehaviorReports in the 1990s and 2000s showed that kappa opioid receptor (KOR) agonists might be promising for treatment and/or prevention of opioid use disorder (OUD) and cocaine use disorder (CUD). However, the side effects associated with KOR agonists available at the time, such as psychotomimesis, dysphoria and sedation, prevented clinical development ...
Lee-Yuan, Liu-Chen, Peng, Huang
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Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial
Science Translational MedicineMetabotropic glutamate receptor 5 (mGluR5) is involved in cocaine reward processing and addiction. Preclinical studies suggest that blocking this receptor inhibits cocaine self-administration and seeking behavior in rodents. We assessed a selective noncompetitive antagonist of mGluR5 called mavoglurant in a phase 2 randomized, placebo ...
Baltazar Gomez-Mancilla +16 more
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Cardiovascular disorders associated with cocaine use: myths and truths
Pharmacology & Therapeutics, 2003Cocaine produces a pattern of cardiovascular responses that are associated with apparent myocardial ischemia, arrhythmias, and other life-threatening complications in some individuals. Despite recent efforts to better understand the causes of cocaine-induced cardiovascular dysfunction, there remain a number of unanswered questions regarding the ...
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COCAINE USE DISORDER. MONOGRAPHIC ARTICLE
Revista sanitaria de investigación, 2023Amor Rosillo María Pilar +5 more
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