Results 171 to 180 of about 66,419 (330)

Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The purpose of this study is to identify the earliest appearing auditory electrophysiological indicators that change with age progression in young adults with normal hearing, and to analyze the frequency distribution patterns of these markers in the cochlear.
Min‐Fei Qian   +6 more
wiley   +1 more source

DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy

open access: yesAging Cell, EarlyView.
In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding   +8 more
wiley   +1 more source

Where hearing starts: the development of the mammalian cochlea

open access: yesJournal of Anatomy, 2016
Martin L Basch   +3 more
semanticscholar   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

open access: yesAging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini   +14 more
wiley   +1 more source

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