Otosclerosis under microCT: New insights into the disease and its anatomy
Frontiers in Radiology, 2022 PurposeOtospongiotic plaques can be seen on conventional computed tomography (CT) as focal lesions around the cochlea. However, the resolution remains insufficient to enable evaluation of intracochlear damage.
Gabriela O'Toole Bom Braga +5 more
doaj +1 more source
The Development of a Single Frequency Place in the Mammalian Cochlea: The Cochlear Resonance in the Mustached Bat Pteronotus parnellii [PDF]
, 2003 Cochlear microphonic potentials (CMs) were recorded from the sharply tuned, strongly resonant auditory foveae of 1- to 5-week-old mustached bats that were anesthetized with Rompun and Ketavet.
Drexl, Markus +4 more
core +2 more sources
Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]
, 2017 open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura +6 more
core +2 more sources
Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]
, 2017 Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali +12 more
core +2 more sources
Alternative splicing in shaping the molecular landscape of the cochlea
Frontiers in Cell and Developmental Biology, 2023 The cochlea is a complex organ comprising diverse cell types with highly specialized morphology and function. Until now, the molecular underpinnings of its specializations have mostly been studied from a transcriptional perspective, but accumulating ...
Kwan Soo Kim +5 more
doaj +1 more source
The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss [PDF]
, 2018 Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells ...
Asmita Dhukhwa +8 more
core +4 more sources
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Electroacoustic Responsive Cochlea‐on‐a‐Chip
Advances in MaterialsOrgan‐on‐chips can highly simulate the complex physiological functions of organs, exhibiting broad application prospects in developmental research, disease simulation, as well as new drug research and development.
Yangnan Hu +15 more
semanticscholar +1 more source
Age-Related Changes in Immune Cells of the Human Cochlea
Frontiers in Neurology, 2019 Age-related hearing loss is a chronic degenerative disorder affecting one in two individuals above the age of 75. Current population projections predict a steady climb in the number of older individuals making the search for interventions to prevent or ...
Kenyaria V. Noble +4 more
semanticscholar +1 more source
The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]
, 2009 Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen +2 more
core +1 more source