Results 51 to 60 of about 50,225 (239)

Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]

, 2013
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science
The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions.
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
doaj   +1 more source

Developmental expression of inositol 1, 4, 5-trisphosphate receptor in the post-natal rat cochlea

European Journal of Histochemistry, 2015
Inositol 1, 4, 5-trisphosphate receptor (IP3R) has been established to be essential for hearing. However, the expression of IP3R in the cochlea in the period of auditory development remains unknown.
W.J. Liu, J. Yang
doaj   +1 more source

Age-Related Hearing Loss Is Accompanied by Chronic Inflammation in the Cochlea and the Cochlear Nucleus

Frontiers in Aging Neuroscience, 2022
Age-related hearing loss (ARHL) is a major hearing impairment characterized by pathological changes in both the peripheral and central auditory systems.
Benjamin J. Seicol, Benjamin J. Seicol, Shengyin Lin, Ruili Xie, Ruili Xie   +4 more
doaj   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Deafness gene expression patterns in the mouse cochlea found by microarray analysis.

PLoS ONE, 2014
BackgroundTonotopy is one of the most fundamental principles of auditory function. While gradients in various morphological and physiological characteristics of the cochlea have been reported, little information is available on gradient patterns of gene ...
Hidekane Yoshimura, Yutaka Takumi, Shin-ya Nishio, Nobuyoshi Suzuki, Yoh-ichiro Iwasa, Shin-ichi Usami   +5 more
doaj   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice. [PDF]

PLoS ONE, 2008
Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans. Because the mechanisms
Qing Chang, Wenxue Tang, Shoeb Ahmad, Binfei Zhou, Xi Lin   +4 more
doaj   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Cochlear-bone wave can yield a hearing sensation as well as otoacoustic emission

, 2014
A hearing sensation arises when the elastic basilar membrane inside the cochlea vibrates. The basilar membrane is typically set into motion through airborne sound that displaces the middle ear and induces a pressure difference across the membrane.
Reichenbach, T., Tchumatchenko, T.
core   +1 more source