Results 121 to 130 of about 398,151 (282)
Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To investigate effects of repeated training with anatomically varied versus identical 3D‐printed models on skill acquisition, cognitive load, and skill retention in novice mastoidectomy trainees. Study Design A prospective, randomized, controlled, educational trial conducted April to September 2024 including a 3‐month retention test.
Adam Omari +4 more
wiley +1 more source
Pulsatile electrical stimulation of auditory nerve fibres : a modelling approach [PDF]
A stochastic leaky integrate-and-fire nerve model with a dynamical threshold (LIFDT) has been derived for the neural response to sinusoidal electrical stimulation.
Chen, Xisha
core
Effects of Minority Status on Sensory Outcomes, Cognition, and Depression
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To evaluate the association between minority status and sensory function, sleep quality, depressive symptoms, and cognitive performance in an aging population. Study Design Prospective, cross‐sectional study. Setting Participants were recruited from the Department of Otolaryngology and the Center for Cognitive Neuroscience and Aging ...
Ivette Cejas +9 more
wiley +1 more source
Nonthermal plasma approaches for combating implant‐associated infections: A compendious review
VIEW, EarlyView.Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe +8 more
wiley +1 more source
Advances in deep‐tissue fluorescence imaging through optical clearing: A review
VIEW, EarlyView.Optical clearing refers to techniques that are used to improve the optical transparency of biological tissues. Optical clearing enables imaging of deeper lying tissues as well as 3D volumetric imaging of whole organs. This review examines reports on the integration of optical clearing with advanced fluorescence imaging techniques, with particular ...
Alaka Pramod +4 more
wiley +1 more source
, 2010 The discovery of otoacoustic emissions (OAE) has advanced our understanding of cochlear mechanics and the efferent auditory system. OAE are sounds generated withinnormal cochlea either spontaneously or in response to stimulation.
Mishra, Srikanta Kumar
core +1 more source
VIEW, EarlyView.Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan +4 more
wiley +1 more source
Useful residual hearing despite radiological findings suggestive of anacusis [PDF]
, 1999 A severe malformation of the inner ear, often referred to as severe labyrinthine dysplasia or common cavity deformity, consists of an absent or dilated cochlear basal coil, wide communication with the vestibule and a tapered internal acoustic meatus and ...
Mahoney, CO, Sirimanna, T, Bamiou, DE
core
Speech Recognition Deficits in Presbyacusis: Links to Cortical Structural and Functional Alterations
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective To characterize speech recognition in presbyacusis and its associated neurophysiological and cortical structural features, and to explore structure‐function‐behavior relationships within the presbyacusis phenotype. Methods Thirty elderly patients with presbyacusis(HI) and thirty‐three healthy young controls(NH) completed a behavioral
Xiao‐Qian Ren +8 more
wiley +1 more source