A spectrally and kinetically multiplexed single‐molecule imaging method is developed, which achieved simultaneous imaging of 12 exosomal proteins at an unparalleled single‐copy resolution. It is found that co‐occurrence of α6 integrin and the pairing β counterpart on single exosomes is essential for lung targeting, providing valuable information for ...
Songlin Liu +10 more
wiley +1 more source
Robust Hippocampal Synaptic Plasticity Despite Gut Microbiota Depletion in Adult Mice. [PDF]
Collins MK +5 more
europepmc +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source
Author Correction: Phage therapy with nebulized cocktail BX004-A for chronic Pseudomonas aeruginosa infections in cystic fibrosis: a randomized first-in-human trial. [PDF]
Weiner I +43 more
europepmc +1 more source
In-cell NMR spectra of chemically unmodified RNA at physiological temperature with extended lifetime through RNase inhibitor cocktail in living human cells. [PDF]
Eladl O +3 more
europepmc +1 more source
Genomic and in vitro characterization of two lytic bacteriophages infecting multidrug-resistant Erwinia sp. strain AnSW2-5. [PDF]
Baek K, Goh J, Choi A.
europepmc +1 more source
The Effect of Cocktail Formula Solution for Erector Spinae Plane Block on Postoperative Pain After Laparoscopic Major Upper Abdominal Surgery: A Single-Center Randomized Controlled Study. [PDF]
Lu D +8 more
europepmc +1 more source
Pharmacodynamic individualization of phage therapy against a KPC-5-producing Pseudomonas aeruginosa. [PDF]
Nguyen TD +7 more
europepmc +1 more source
Impact of phage treatment on fire blight disease outcome and floral microbiome composition. [PDF]
Holtappels D, Wu KU, Koskella B, Roh E.
europepmc +1 more source

