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Rational Design of a Phage Cocktail for Effective Control of Multidrug-Resistant Uropathogenic Escherichia coli from Hospitalized Patients [PDF]

Antibiotics
Background: The emergence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) poses a significant public health challenge, and alternative treatments are urgently needed. Methods: Here, we identified clinical MDR-UPEC strains AT82 and AT84
Patiphan Khunti, Panupon Mongkolkarvin, Songphon Buddhasiri, Joe Pogliano, Poochit Nonejuie, Parameth Thiennimitr, Vorrapon Chaikeeratisak   +6 more
doaj   +2 more sources

A broad-host-range inhalable phage cocktail for treatment of multidrug-resistant Pseudomonas aeruginosa pulmonary infections [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionThe growing threat of multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) has created an urgent need for novel therapeutic strategies to combat refractory lung infections.
Zixun Lin, Zixun Lin, Xiaofu Wan, Xiangke Duan, Xiangke Duan, Shuang Liang, Xiaoqian Wang, Jiuxin Qu, Chuandong Zhou, Min Ming, Yukun Zeng, Shuhong Han, Shuhong Han, Yijia Ling, Wenheng Gan, Ke Wang, Liang Yang, Xin Zhou, Hongzhou Lu, Hongzhou Lu, Jiayin Shen   +20 more
doaj   +2 more sources

Inhibition of Antimicrobial-Resistant Escherichia coli Using a Broad Host Range Phage Cocktail Targeting Various Bacterial Phylogenetic Groups

Frontiers in Microbiology, 2021
Antimicrobial-resistant (AMR) commensal Escherichia coli is a major reservoir that disseminates antimicrobial resistance to humans through the consumption of contaminated foods, such as retail poultry products. This study aimed to control AMR E.
Sangryeol Ryu, Byeonghwa Jeon, Jinshil Kim   +2 more
exaly   +3 more sources

Broad-spectrum phage cocktail targeting Campylobacter improves survival in Galleria mellonella, a bridging host model for poultry biocontrol [PDF]

Frontiers in Microbiology
Campylobacter jejuni and Campylobacter coli are the main agents of campylobacteriosis, a globally prevalent foodborne illness predominantly linked to the consumption of contaminated poultry products.
Estibaliz Ruiz-Santamaría, Estibaliz Ruiz-Santamaría, Amaia Lasagabaster, Gaizka Carregal, Katherine Miranda-Cadena, Estibaliz Mateo   +5 more
doaj   +2 more sources

Evaluating the effectiveness and safety of a novel phage cocktail as a biocontrol of Salmonella in biofilm, food products, and broiler chicken [PDF]

Frontiers in Microbiology
Salmonella is a foodborne pathogen of animal and public health significance. Considering the disadvantages of antibiotics or chemical preservatives traditionally used to eliminate this pathogen, attention has shifted, in recent years, toward biocontrol ...
Narges Torkashvand, Haniyeh Kamyab, Haniyeh Kamyab, Parisa Aarabi, Ahmad Reza Shahverdi, Ahmad Reza Shahverdi, Mohammad Amir Karimi Torshizi, Mohammad Reza Khoshayand, Mohammad Reza Khoshayand, Zargham Sepehrizadeh, Zargham Sepehrizadeh   +10 more
doaj   +2 more sources

From Isolation to Application: Designing a Multi-Target Phage Cocktail for Bivalve Safety [PDF]

Microorganisms
Narrow host specificity and bacterial resistance often limit single-phage treatments. Phage cocktails address these challenges by expanding the host range, reducing resistance, and enhancing bacterial inactivation.
Pedro Costa, Carla Pereira, Jesús L. Romalde, Adelaide Almeida   +3 more
doaj   +2 more sources

Precision Phage Cocktail Targeting Surface Appendages for Biocontrol of Salmonella in Cold-Stored Foods [PDF]

Antibiotics
Salmonella enterica is a major food-borne pathogen causing food poisoning. The use of bacteriophages as alternative biocontrol agents has gained renewed interest due to the rising issue of antibiotic-resistant bacteria.
Seongok Kim, Bokyung Son, Hyeryen Kim, Hakdong Shin, Sangryeol Ryu   +4 more
doaj   +2 more sources

A Klebsiella-phage cocktail to broaden the host range and delay bacteriophage resistance both in vitro and in vivo [PDF]

npj Biofilms and Microbiomes
Bacteriophages (phages), viruses capable of infecting and lysing bacteria, are a promising alternative for treating infections from hypervirulent, antibiotic-resistant pathogens like Klebsiella pneumoniae, though narrow host range and phage resistance ...
Huanchang Chen, Haifeng Liu, Yanchun Gong, Rhys A. Dunstan, Zhexiao Ma, Cui Zhou, Deyi Zhao, Miran Tang, Trevor Lithgow, Tieli Zhou   +9 more
doaj   +2 more sources

Phage Cocktail Alleviates Bacterial Canker of Kiwifruit by Modulating Bacterial Community Structure in Field Trial [PDF]

Microorganisms
Bacterial canker of kiwifruit is the most destructive bacterial disease caused by Pseudomonas syringae pv. actinidiae. Bacteriophages are regarded as promising biocontrol agents against kiwifruit bacterial pathogens due to their exceptional host ...
Ran Hu, Xiaohan Xu, Yajun Jia, Cancan Zhu, Lin Wang, Minxin Song, Qian Xu, Mian Xia, Xiaoqing He, Yi Jin   +9 more
doaj   +2 more sources

Efficiency, cytotoxicity, and survivability evaluation of Salmonella phage cocktail against Salmonella derived from broiler sources [PDF]

Veterinary World
Background and Aim: Salmonella is a leading cause of foodborne illnesses worldwide, often linked to poultry products. Antibiotic resistance among Salmonella strains has increased the need for alternative decontamination strategies, such as bacteriophage (
Wattana Pelyuntha, Thamonwan Narkpao, David Yembilla Yamik, Pichamon Kiatwuthinon, Arsooth Sanguankiat, Attawit Kovitvadhi, Kitiya Vongkamjan   +6 more
doaj   +2 more sources