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Bacteriophage Therapy in Companion and Farm Animals. [PDF]

Antibiotics (Basel)
Bacteriophages, which are viruses with restricted tropism for bacteria, have been employed for over a century as antimicrobial agents; they have been largely abandoned in Western countries but are constantly used in Eastern European countries with the advent of antibiotics.
Bianchessi L, De Bernardi G, Vigorelli M, Dall'Ara P, Turin L.   +4 more
europepmc   +5 more sources

Bacteriophage Therapy [PDF]

Annual Review of Microbiology, 2001
▪ Abstract  In 1917, bacteriophages were recognized as epizootic infections of bacteria and were almost immediately deployed for antibacterial therapy and prophylaxis. The early trials of bacteriophage therapy for infectious diseases were confounded, however, because the biological nature of bacteriophage was poorly understood.
A, Sulakvelidze, Z, Alavidze, J G, Morris   +2 more
  +6 more sources

Campylobacter bacteriophages and bacteriophage therapy. [PDF]

Journal of applied microbiology, 2011
Members of the genus Campylobacter are frequently responsible for human enteric disease with occasionally very serious outcomes. Much of this disease burden is thought to arise from consumption of contaminated poultry products. More than 80% of poultry in the UK harbour Campylobacter as a part of their intestinal flora.
P L, Connerton, A R, Timms, I F, Connerton   +2 more
openaire   +2 more sources

Animal Models in the Evaluation of the Effectiveness of Phage Therapy for Infections Caused by Gram-Negative Bacteria from the ESKAPE Group and the Reliability of Its Use in Humans

Microorganisms, 2021
The authors emphasize how extremely important it is to highlight the role played by animal models in an attempt to determine possible phage interactions with the organism into which it was introduced as well as to determine the safety and effectiveness ...
Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
doaj   +1 more source

Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

Cells, 2021
Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal
Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
doaj   +1 more source

The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy

Antibiotics, 2021
Acinetobacter baumannii are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics.
Natalia Bagińska, Martyna Cieślik, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
doaj   +1 more source

Biological Properties of 12 Newly Isolated Acinetobacter baumannii-Specific Bacteriophages

Viruses, 2023
Infections with the opportunistic Gram-negative bacterium Acinetobacter baumannii pose a serious threat today, which is aggravated by the growing problem of multi-drug resistance among bacteria, caused by the overuse of antibiotics.
Natalia Bagińska, Marek Adam Harhala, Martyna Cieślik, Filip Orwat, Beata Weber-Dąbrowska, Krystyna Dąbrowska, Andrzej Górski, Ewa Jończyk-Matysiak   +7 more
doaj   +1 more source

Bacteriophage Therapy ofSalmonella enterica:A Fresh Appraisal of Bacteriophage Therapy [PDF]

The Journal of Infectious Diseases, 2010
The most serious criticisms leveled at bacteriophage therapy are as follows: phages induce neutralizing antibodies, phages are active only when administered shortly after bacterial infection, and phage-resistant bacteria emerge rapidly in the course of therapy.Phages lytic for several Salmonella enterica serovars were isolated by means of standard ...
CAPPARELLI, ROSANNA, N. Nocerino, IANNACCONE, MARCO, D. Ercolini, M. Parlato, M. Chiara, D. Iannelli   +6 more
openaire   +6 more sources

Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies

Frontiers in Immunology, 2021
Bacteriophages are able to affect the human immune system. Phage-specific antibodies are considered as major factors shaping phage pharmacokinetics and bioavailability.
Zuzanna Kaźmierczak, Zuzanna Kaźmierczak, Joanna Majewska, Paulina Miernikiewicz, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Sylwia Nowak, Marek Harhala, Dorota Lecion, Weronika Kęska, Barbara Owczarek, Jarosław Ciekot, Marek Drab, Paweł Kędzierski, Marta Mazurkiewicz-Kania, Andrzej Górski, Krystyna Dąbrowska   +16 more
doaj   +1 more source

Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far

Journal of Biomedical Science, 2022
Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of phages and antibiotics separately or in ...
Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knežević, Cyprian Winogradow, Karolina Amaro, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Justyna Rękas, Andrzej Górski   +10 more
doaj   +1 more source