Results 41 to 50 of about 48,920 (278)

Bacteriophage Therapy

, 2023
A Virus that infects bacteria and replicates within a bacterium. Bacteriophage is derived from Greek, Backerion means bacteria, and Phage means to eat. Obligate intracellular parasites that multiply inside bacteria by making use of all the host biosynthetic machinery.
openaire   +1 more source

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Viruses, 2017
Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic ...
Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Barbara Owczarek, Ryszard Międzybrodzki, Marzanna Łusiak-Szelachowska, Norbert Łodej, Andrzej Górski   +6 more
doaj   +1 more source

Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

, 2020
This is a case of a 72 year old male with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage
Vincent Y. Ng, Bri’Anna Horne, Joseph Fackler, Matthew Henry, Aaron J. Johnson, Michael J. Brownstein, Biswajit Biswas, Francisco Malagon, James B. Doub, Magdalena Slomka   +9 more
core   +1 more source

Isolation and Characterization of Phages Active against Paenibacillus larvae Causing American Foulbrood in Honeybees in Poland

Viruses, 2021
The aim of this study was the isolation and characterization, including the phage effect on honeybees in laboratory conditions, of phages active against Paenibacillus larvae, the causative agent of American Foulbrood—a highly infective and easily ...
Ewa Jończyk-Matysiak, Barbara Owczarek, Ewa Popiela, Kinga Świtała-Jeleń, Paweł Migdał, Martyna Cieślik, Norbert Łodej, Dominika Kula, Joanna Neuberg, Katarzyna Hodyra-Stefaniak, Marta Kaszowska, Filip Orwat, Natalia Bagińska, Anna Mucha, Agnieszka Belter, Mirosława Skupińska, Barbara Bubak, Wojciech Fortuna, Sławomir Letkiewicz, Paweł Chorbiński, Beata Weber-Dąbrowska, Adam Roman, Andrzej Górski   +22 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes

Journal of Immunology Research, 2015
Intracellular killing of bacteria is one of the fundamental mechanisms against invading pathogens. Impaired intracellular killing of bacteria by phagocytes may be the reason of chronic infections and may be caused by antibiotics or substances that can be
Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Marlena Kłak, Barbara Bubak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Maciej Żaczek, Wojciech Fortuna, Paweł Rogóż, Sławomir Letkiewicz, Krzysztof Szufnarowski, Andrzej Górski   +11 more
doaj   +1 more source

Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy

, 2021
Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant ...
Vincent Y. Ng, Benjamin K. Chan, James B. Doub, Eleanor Wilson, Lorenzo Corsini   +4 more
core   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Comprehensive Approaches to Combatting Acinetobacter baumannii Biofilms: From Biofilm Structure to Phage-Based Therapies

Antibiotics
Acinetobacter baumannii—a multidrug-resistant (MDR) pathogen that causes, for example, skin and soft tissue wounds; urinary tract infections; pneumonia; bacteremia; and endocarditis, particularly due to its ability to form robust biofilms—poses a ...
Ilona Grygiel, Olaf Bajrak, Michał Wójcicki, Klaudia Krusiec, Ewa Jończyk-Matysiak, Andrzej Górski, Joanna Majewska, Sławomir Letkiewicz   +7 more
doaj   +1 more source

The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy

, 2023
International audienceFor decades, biomedically centered studies of bacteria have focused on mechanistic drivers of disease in their mammalian hosts.
Zborowsky, Sophia, Weitz, Joshua, S, Marchi, Jacopo, Debarbieux, Laurent   +3 more
core   +1 more source