Results 191 to 200 of about 16,526 (214)
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Cocrystal: A Review on the Design and Preparation of Pharmaceutical Cocrystals
Asian Journal of Research in Pharmaceutical Sciences, 2023The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour.
Tanmay Jit +4 more
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International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
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Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto +2 more
openaire +2 more sources
Can We Identify the Salt–Cocrystal Continuum State Using XPS?
, 2020X-ray Photoelectron Spectroscopy (XPS) is used to understand the nature of acid-base crystalline solids, to know whether the product is a salt (proton transfer, O···HN+) or cocrystal (neutral add...
Srinu Tothadi +5 more
semanticscholar +1 more source
Advanced methodologies for cocrystal synthesis
Advanced Drug Delivery Reviews, 2017Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties of Active Pharmaceutical Ingredients (APIs) such as ...
Dennis Douroumis +2 more
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Ketoconazole - p-aminobenzoic acid cocrystal: revival of an old drug by crystal engineering.
Molecular Pharmaceutics, 2020The 1:1 cocrystal of the antifungal agent Ketoconazole with p-aminobenzoic acid was successfully crystallized and systematically characterized from a physical and pharmacological point of view.
F. Martin +12 more
semanticscholar +1 more source
2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
openaire +1 more source
The aim of this project is to improve cocrystal screening and solubility prediction methods.
openaire +1 more source
European Journal of Pharmaceutical Sciences, 2020
Cocrystals that are more soluble than the constituent drug, generate supersaturation levels during dissolution and are predisposed to conversion to the less soluble drug.
T. C. Machado +3 more
semanticscholar +1 more source
Cocrystals that are more soluble than the constituent drug, generate supersaturation levels during dissolution and are predisposed to conversion to the less soluble drug.
T. C. Machado +3 more
semanticscholar +1 more source
2017
The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
openaire +1 more source
The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
openaire +1 more source
, 2020
The successful synthesis of multi-component molecular solids such as cocrystals typically requires a large number of experiments before a new solid form of the target compound emerges with improved bulk properties.
N. Sarkar +4 more
semanticscholar +1 more source
The successful synthesis of multi-component molecular solids such as cocrystals typically requires a large number of experiments before a new solid form of the target compound emerges with improved bulk properties.
N. Sarkar +4 more
semanticscholar +1 more source
A melt castable energetic cocrystal
Chemical Communications, 2017Cocrystallization leads to melt-state stabilization of the thermally unstable energetic 4-amino-3,5-dinitropyrazole, allowing for production of a melt castable cocrystalline explosive.
Jonathan C. Bennion +2 more
openaire +2 more sources