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N‑Terminal Protein Complexation and Assembly with a Triangular Sulfated Macrocycle. [PDF]

Cryst Growth Des
Ifeagwu MC, Guo L, Mockler NM, Dong M, Li C, Crowley PB.   +5 more
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Inhibiting Sublimation of Thymol by Cocrystallization

Journal of Pharmaceutical Sciences, 2023
A thymol:4,4'-dipyridyl (2:1) cocrystal (Form I) is reported to suppress thymol sublimation. The cocrystal was prepared via solution-mediated phase transformation and its structure is sustained by O-H (phenol) ··· N (pyridyl) hydrogen bonds between two individual components.
Hui Zu, Rodger F. Henry, Geoff G.Z. Zhang, Leonard R. MacGillivray   +3 more
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Mitigating Drug Stability Challenges Through Cocrystallization

AAPS PharmSciTech, 2023
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire life cycle of a product. Various formulation approaches have been employed to overcome drug stability issues.
Jamshed Haneef, Mohd Amir, Nadeem Ahmed Sheikh, Renu Chadha   +3 more
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Programmable Cocrystallization of DNA Origami Shapes

Journal of the American Chemical Society, 2020
Assembly of distinct types of species, particularly possessing anisotropic configurations, is the premise to broaden structural diversity and explore materials' collective properties. However, it remains a great challenge to programmably cocrystallize manifold anisotropic nanoparticles with the desired assembly mode, because it requires not only the ...
Min Ji, Jiliang Liu, Lizhi Dai, Lei Wang, Ye Tian   +4 more
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Cocrystallization of melaminium levulinate monohydrate

Acta Crystallographica Section C Crystal Structure Communications, 2004
Crystals of 2,4,6-triamino-1,3,5-triazin-1-ium levulinate (4-oxopentanoate) monohydrate, C(3)H(7)N(6)(+).C(5)H(7)O(3)(-).H(2)O, are formed via self-assembled hydrogen bonding by cocrystallization of melamine and levulinic acid. Two N-H.N hydrogen bonds and four N-H.O hydrogen bonds connect two melaminium entities such that each of two pairs of N-H.O ...
Chan Soo, Choi, Ramaiyer, Venkatraman, Eun Hee, Kim, Hae Sook, Hwang, Sung Kwon, Kang   +4 more
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Cocrystallization of Atomically Precise Nanoclusters

ACS Materials Letters, 2020
Of the great classes of nanocluster crystallization, “cocrystallization” has gained significant attention due to its elucidation of both intracluster structures and intercluster packing modes.
Xi Kang, Manzhou Zhu
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Pharmaceutical cocrystallization techniques. Advances and challenges

International Journal of Pharmaceutics, 2018
Cocrystals are homogenous (single-phase) crystalline structures composed by two or more components in a definite stoichiometric ratio bonded together by noncovalent bonds. Pharmaceutical industry has been showing interest in cocrystals due to their ability to improve active pharmaceutical ingredients (API's) properties, such as solubility, dissolution,
Marisa, Rodrigues, Bárbara, Baptista, João Almeida, Lopes, Mafalda Cruz, Sarraguça   +3 more
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Cocrystallization for successful drug delivery

Expert Opinion on Drug Delivery, 2012
Cocrystallization is an effective crystal engineering approach for modifying the crystal structure and properties of drugs. The number of examples of solving drug formulation and manufacture problems by cocrystallization is rapidly growing. An updated review that systematically examines the cocrystal research in the context of drug delivery is timely ...
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Cocrystallization of Proinsulin and Insulin

Nature, 1973
THE occurrence of small amounts of proinsulin in crystalline preparations of bovine, porcine, and rat insulin1–4 and the many similarities in properties of proinsulin and insulin prompted us to consider the possibility that proinsulin co-crystallizes with insulin.
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