Results 71 to 80 of about 7,020,561 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2013 Written in the style of novelist Dan Brown and using actual quotations from Puccini’s letters and other documents, the author creates the characters Prof.
Burton, Deborah
core
, 2012 Many quantum systems are being investigated in the hope of building a large-scale quantum computer. All of these systems suffer from decoherence, resulting in errors during the execution of quantum gates. Quantum error correction enables reliable quantum
A. G. Fowler +6 more
core +2 more sources
Editorial: Big code, little code, open code, old code
Code4Lib Journal, 2023 Paraphrasing the title of Christine L. Borgman’s inaugural lecture in Göttingen some years ago “Big data, little data, open data” I could say that the current issue of Code4Lib is about big code, little code, open code, old code. The good side of coding is that effective contribution could be done with different levels and types of background knowledge.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
LEGAL FRAMEWORK FOR FAMILY POLICY BASHKIR ASSR IN 1917-1937-th
Вестник Северо-Кавказского федерального университета, 2022 The article examines the peculiarities of the legal framework of the Soviet family policy in 1917-1937 gg. in the Bashkir ASSR. Analyzes the content and application of legal acts of the state. The author has attempted to show how the legislative activity
Gashura G. Gnıуаtullınа
doaj
Conversion of palatal rugae pattern to scanable Quick Response code in an Arabian population
Journal of Dental Sciences, 2016 Backgroud/purpose: Palatal rugae (PR) are situated in the anterior part of the hard palate and possess unique and stable characteristics that can be used in human identification.
Sadatullah Syed +5 more
doaj +1 more source
Nature Communications80 pages, 33 figures; v2 substantial changes to improve ...
Dominic J. Williamson, Nouédyn Baspin
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source