Results 81 to 90 of about 2,599,751 (310)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
El rigor del código caballeresco artúrico en el Medievo
Nous nous proposons d'analyser dans ce travail les divers codes régissant les comportements sociaux, amoureux, guerriers et religieux du chevalier arthurien.
María Aurora GARCÍA RUIZ
doaj +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
AI and Theology: The Battle of Metaphors and the Fate of Humanity [PDF]
Artificial intelligence continues to reshape the prevailing imageries of knowledge, identity, and values of humans. These emerging developments intensify the battle of metaphors in the contemporary Theo-tech domain.
Zia ul Haq
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
This manual is designed to provide building department personnel with specific inspection and plan review skills and information on provisions of the 1991 edition of the Washington State Energy Code (WSEC).
Washington (State). State Building Code Advisory Council. Energy Code Committee.
core +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Exploring the Landscape of Programming Language Identification With Machine Learning Approaches
The increasing complexity of modern software development necessitates tools and methodologies for code analysis, maintenance, and migration in multi-language Integrated Development Environments (IDEs).
Amandeep Verma +5 more
doaj +1 more source

