Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
International Building Code: 2009 [PDF]
Manual describing best practices for constructing buildings that meet safety and energy requirements; appropriate building materials and use; and related issues: "This comprehensive building code establishes minimum regulations for building systems using
International Code Council
core
Clone-World: A visual analytic system for large scale software clones
With the era of big data approaching, the number of software systems, their dependencies, as well as the complexity of the individual system is becoming larger and more intricate.
Debajyoti Mondal +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Scalable Source Code Similarity Detection in Large Code Repositories [PDF]
Source code similarity are increasingly used in application development to identify clones, isolate bugs, and find copy-rights violations. Similar code fragments can be very problematic due to the fact that errors in the original code must be fixed in ...
Firas Alomari, Muhammed Harbi
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Enhancing Code Clone Management by Prioritizing Code Clones [PDF]
Master of Engineering-ThesisSoftware development is often accompanied by the activities of reusing exisiting software, with or without modification, along with building application from scratch.
Garg, Ridhi
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A Novel Method for Code Clone Detection Based on Minimally Random Kernel Convolutional Transform
Effectively detecting code clones is essential for maintaining and evolving software systems. This paper introduces a novel approach that leverages minimally random kernel convolutional transform (MiniRocket) to represent source code for clone detection.
Mostefai Abdelkader
doaj +1 more source
Test-Based Clone Detection: an Initial Try on Semantically Equivalent Methods
Most code clone detection approaches identify clones via static source code analysis. Such approaches are effective and efficient in detecting lexically similar clones.
Guangjie Li +3 more
doaj +1 more source

