Results 41 to 50 of about 115,619 (216)

Towards grain-scale modelling of the release of radioactive fission gas from oxide fuel. Part II: Coupling SCIANTIX with TRANSURANUS

Nuclear Engineering and Technology, 2022
The behaviour of the fission gas plays an important role in the fuel rod performance. In a previous work, we presented a physics-based model describing intra- and inter-granular behaviour of radioactive fission gas. The model was implemented in SCIANTIX,
G. Zullo, D. Pizzocri, A. Magni, P. Van Uffelen, A. Schubert, L. Luzzi   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

An Open-Source Code for Fluid Flow Simulations in Unconventional Fractured Reservoirs

Geosciences, 2021
In this article, an open-source code for the simulation of fluid flow, including adsorption, transport, and indirect hydromechanical coupling in unconventional fractured reservoirs is described.
Bin Wang, Corrado Fidelibus
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Parametric study of midplane gas puffing to maximize ICRF power coupling in ITER

Nuclear Fusion, 2023
Midplane gas puffing close to the ion cyclotron range of frequencies (ICRF) antennae has been demonstrated to be robust in improving ICRF power coupling in current tokamaks. It is also shown in a previous study (Zhang 2019 Nucl. Mater.
W. Zhang, A. Messiaen, W. Helou, V. Bobkov, P. Lamalle, R.A. Pitts, W. Tierens   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Finite Element Based Multi-dimension and Multi-physics Coupling Analysis for Nuclear Reactor System

Yuanzineng kexue jishu
The nuclear reactor system is complex and the operating environment is harsh, resulting in the complex phenomena of multi-physics coupling. The multi-physics coupling codes developed in the early stage shows limitations on codes' scalability and ...
WU Yingwei, HE Yanan, ZHANG Jing, TIAN Wenxi, SU Guanghui, QIU Suizheng
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multi-physics Coupling Performance Analysis Method of Fast Reactor Fuel Assembly Based on ICoCo Interface

Yuanzineng kexue jishu
The development of a multi-physics coupling program for the fast reactor fuel assembly was presented in this paper. The fuel performance analysis code KMC-Fueltra and the sub-channel analysis code KMC-Subtra were coupled based on the ICoCo interface to ...
YANG Guangliang1, , LIU Zhenhai1, WANG Haoyu1, XIN Yong1, LI Yuanming1, FENG Wenpei2, DONG Sifan3, CHEN Hongli3
doaj   +1 more source