Results 101 to 110 of about 2,054,685 (293)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Code coverage analysis and test case generation [PDF]

, 2018
Cílem této práce je vytvoření metody pro generování testovacích scénářů a vyhodnocení jejich effektivity. Tato metoda je vytvořená na základě analýzy konkrétního programu, která je založená na určení dopadů, jaký mají jednotlivé parametry programu na ...
Sýkora Kryštof
core  

$\theta$-Generalized monomial codes

Journal of Algebra Combinatorics Discrete Structures and Applications
In this paper we generalize cyclic codes to another more large linear codes, that is $\theta$-monomial codes. It is shown that for a $\theta$-monomial code, its Euclidean and $e$-Galois dual is also  $\theta$-monomial code. Furthermore we present the equivalence between $\theta$-monomial codes and generalized monomial codes.
Mouatadid, Lhousain, Kabbouch, Oussama, Mouloua, El Mahdi, Najmeddine, Mustapha   +3 more
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Navigating the Pitfalls: Analyzing the Behavior of LLMs as a Coding Assistant for Computer Science Students—A Systematic Review of the Literature

IEEE Access
In recent years, large language models (LLMs) have been employed significantly in different domains of computing education. Nevertheless, these models have been focused on essential adherence to their integration as coding assistants in computing ...
Farman Ali Pirzado, Awais Ahmed, Roman Alejandro Mendoza-Urdiales, Hugo Terashima-Marin   +3 more
doaj   +1 more source

PyRates-A code-generation tool for modeling dynamical systems in biology and beyond. [PDF]

PLoS Comput Biol, 2023
Gast R, Knösche TR, Kennedy A.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Towards Product Lining Model-Driven Development Code Generators [PDF]

, 2015
A code generator systematically transforms compact models to detailed code. Today, code generation is regarded as an integral part of model-driven development (MDD).
Roth, Alexander, Rumpe, Bernhard
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

An Empirical Study of the Code Generation of Safety-Critical Software Using LLMs

Applied Sciences
In the digital era of increasing software complexity, improving the development efficiency of safety-critical software is a challenging task faced by academia and industry in domains such as nuclear energy, aviation, the automotive industry, and rail ...
Mingxing Liu, Junfeng Wang, Tao Lin, Quan Ma, Zhiyang Fang, Yanqun Wu   +5 more
doaj   +1 more source