Results 81 to 90 of about 61,090 (259)

Design of Mapping Matrix for Arithmetic Bit-Interleaved Coded Modulation

open access: yesIEEE Access, 2019
Arithmetic bit-interleaved coded modulation (A-BICM) is a coded rate compatible modulation (RCM). It achieves progressive mapping to strike a trade-off between high signal-to-noise ratio (SNR) and low SNR.
Jinkun Zhu   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Polar-Coded GFDM Systems

open access: yesIEEE Access, 2019
Generalized frequency division multiplexing (GFDM) is a block-based non-orthogonal multicarrier modulation scheme proposed for 5G PHY layer. In this paper, to efficiently coordinate the features of interference existing in the GFDM system, we propose a ...
Yan Li, Kai Niu, Chao Dong
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Fundamental performance limits of CPM coded modulation system

open access: yesTongxin xuebao, 2014
The study of the capacity of CPM systems was concerned with.The definition as well as the Finite-State-Machine (FSM) model of CPM was introduced.The development of calculating the capacity of CPM over AWGN channels was first reviewed.Then this ...
Bing LI, Fan WEI, Bao-ming BAI, Xiao MA
doaj   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Spectral Efficiency Improved 2D-PAM8 Trellis Coded Modulation for Short Reach Optical System

open access: yesIEEE Photonics Journal, 2017
This paper proposes and demonstrates a 31.25 Gbps two-dimensional eight level pulse amplitude modulation with trellis coded modulation (2D-PAM8-TCM) transmission in intensity modulation and direct detection based short reach system. In this system,
Yan Fu   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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