Results 91 to 100 of about 1,341,295 (245)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

On spectra of BCH codes [PDF]

, 1995
Derives an estimate for the error term in the binomial approximation of spectra of BCH codes. This estimate asymptotically improves on the bounds by Sidelnikov (1971), Kasami et al. (1985), and Sole (1990)
Krasikov, I, Simon Litsyn, Litsyn, S, Ilia Krasikov   +3 more
core   +1 more source

Secondary Analysis of Interviews: Using Codes and Theoretical Concepts From the Primary Study

Forum: Qualitative Social Research, 2005
Despite the possibilities of using secondary analysis in social science there are reservations about methodological and ethic issues. Furthermore, the method is under-utilised in Germany due to the lack of readiness and access to the primary data. In our
Irena Medjedovic, Andreas Witzel
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A generalized SEIRW-VN framework for modeling infectious disease dynamics

Scientific Reports
Understanding how infectious diseases spread requires models that integrate both human contact structure and environmental factors. We propose SEIRW-VN, a generalized epidemic framework that combines network heterogeneity, indirect transmission via ...
Abdoulaye Sow, Cherif Diallo, Hocine Cherifi   +2 more
doaj   +1 more source

Does Systems Differentiation Present a Risk for Contemporary Society?

Teorie vědy, 2009
For Niklas Luhmann modern society is a functionally differentiated society, i. e. it is composed of heterogeneous but equal parts which are relatively independent and are defined as social subsystems. Luhmann’s analysis presents contemporary society as a
Jiří Šubrt
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Women in parliaments: Can they enhance environmental sustainability in the EU?

Cleaner Production Letters
Environmental deterioration is a significant and multi-dimensional issue that concerns the modern world. During the last decades, research has been conducted to address this argument, intending to provide holistic policies that drive sustainable ...
Ioannis Kostakis, Paraskevi Angeletopoulou, Eleni Polyzou   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source