Results 101 to 110 of about 173,495,554 (293)

VALUE CREATION THROUGH CORPORATE GOVERNANCE [PDF]

open access: yesCES Working Papers, 2013
Companies spend time and money in order to improve their corporate governance (CG) system and also do not forget to inform third parties about their efforts in this field.
Elena Chitimus
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Drowning in codes of conduct

open access: yes, 2012
Australians face a complex, confusing and often inconsistent environment when it comes to regulating how businesses and consumers should conduct themselves online.This report examines 16 codes of conduct that are relevant to Australian consumers when ...
David Vaile, Chris Connolly
core  

Don’t count your codes before they hatch : a theoretical and empirical analysis of codes of conduct under the General Data Protection Regulation

open access: yes, 2023
The European Union’s General Data Protection Regulation (GDPR) encourages the development of ‘codes of conduct’ in its articles 40-41. Although institutional actors and corporate stakeholders have expressed great interest in such tools, there are still ...
Vander Maelen, Carl
core  

Code of Conduct

open access: yes, 2019
The OBF Code of Conduct was adopted after being voted on by our members in January 2022, following the OBF Public Board meeting in September 2021. Our annual conference, BOSC, is normally run as part of the ISMB meeting, where it therefore follows the OBF Code of Conduct.
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy