Results 121 to 130 of about 173,495,554 (293)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Data protection and codes of conduct in collaborative research [PDF]

open access: yes, 2018
The article aims to describe the current status quo of codes of conduct applied by research institutions to manage data protection issues in light of the General Data Protection Regulation (GDPR). We assessed whether the current codes of conduct meet the
Koščík Michal, Myška Matěj
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Implementing Effective Codes of Conduct: Revisiting the Need for Sound Corporate Governance and Ethical Practice in Corporations

open access: yesJournal of Management & Administration
This article reconnoitres the critical role of employing effective codes of conduct as a basis for sound corporate governance and ethical practice, with reference to South Africa and the global South corporate environment.
Angelo Nicolaides
doaj  

Brief research report: development of codes of conduct in online classrooms for Vietnamese high school students

open access: yesFrontiers in Education
BackgroundIn today's digital age, online education helps eliminate certain barriers faced by traditional education, however, it also presents challenges, including issues related to the culture of conduct among high school students in their relationships
Bui Thanh Thuy   +5 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Between mandatory and aspirational ethics in nursing codes: a case study of the Italian nursing code of conduct

open access: yesBMC Nursing
Background Over the years, national and international nurses’ organisations have drawn up Codes of Conduct and Codes of Ethics. A new differentiation has emerged over time between mandatory and aspirational approaches underlying how nurses can be ...
Stefania Chiappinotto   +4 more
doaj   +1 more source

Balancing public interest, fundamental rights, and innovation: The EU’s governance model for non-high-risk AI systems

open access: yesInternet Policy Review
The question of the concrete design of a fair and efficient governance framework to ensure responsible technology development and implementation concerns not only high-risk artificial intelligence systems.
Michael Gille   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

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