Results 91 to 100 of about 10,130,538 (248)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The qudit Pauli group: non-commuting pairs, non-commuting sets, and structure theorems [PDF]
QuantumQudits with local dimension $d \gt 2$ can have unique structure and uses that qubits ($d=2$) cannot. Qudit Pauli operators provide a very useful basis of the space of qudit states and operators.
Rahul Sarkar, Theodore J. Yoder
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Build-Up Construction for Codes over a Commutative Non-Unitary Ring of Order 9
MathematicsThe build-up method is a powerful class of propagation rules that generate self-dual codes over finite fields and unitary rings. Recently, it was extended to non-unitary rings of order 4, to generate quasi self-dual codes.
Adel Alahmadi +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Hulls of Linear Codes over Non-Unitary Rings of Four Elements
MathematicsIn this paper, we explore the hull of linear codes over the non-unitary rings of order four, namely E, I and H. Initially, we determine the binary associated codes of the hull over each ring; then, we characterize the hulls in terms of these codes ...
Sarra Manseri +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Physics Letters BWe identify Narain conformal field theories (CFTs) that correspond to code lattices for quantum error-correcting codes (QECC) over integers of cyclotomic fields Q(ζp) (ζp=e2πip) for general prime p≥3. This code-lattice construction is a generalization of
Shun'ya Mizoguchi, Takumi Oikawa
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source