Results 261 to 270 of about 204,351 (287)
Some of the next articles are maybe not open access.
Sense from nonsense: therapies for premature stop codon diseases
Trends in Molecular Medicine, 2012Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs.
Laure, Bidou +3 more
openaire +3 more sources
How stop codon pseudouridylation induces nonsense suppression
Computational and Theoretical Chemistry, 2021Abstract Nonsense mutation can be an inherited disorder or caused by genetic mutation under certain conditions such as stress or exposure. Nonsense suppression, can have a broad potential as a therapeutic approach to nonsense mutation. Pseudouridine is proposed to result in nonsense suppression if induced in one of the three nonsense codons, Amber ...
Hadieh Monajemi, Sharifuddin M. Zain
openaire +1 more source
Unassigned or Nonsense Codons in Micrococcus luteus
Journal of Molecular Biology, 1993We previously reported that in Micrococcus luteus, a Gram-positive eubacterium with high genomic G + C content, certain codons ending with A did not appear in coding frames, including termination sites, and tRNAs that translate these codons were not detected. These facts suggest that at least some of them are unassigned (nonsense) codons, i.e.
A, Kano, T, Ohama, R, Abe, S, Osawa
openaire +2 more sources
Nonsense codons and polarity in the tryptophan operon
Journal of Molecular Biology, 1966Abstract Amber and ochre mutants and mutants with cross-reacting material for all five genes of the tryptophan operon have been isolated and characterized. Co-ordinate enzyme formation was examined under repression conditions with a repressordeficient stock of each mutant.
C, Yanofsky, J, Ito
openaire +2 more sources
The BRCA2 polymorphic stop codon: stuff or nonsense?
Journal of Medical Genetics, 2015Background Despite classification of the BRCA2c.9976A>T, p.(Lys3326Ter) variant as a polymorphism, it has been associated with increased risks of pancreatic, lung, oesophageal and breast cancer. Methods We have noticed multiple co-occurrences of ...
Higgs, J E +7 more
openaire +3 more sources
Yeast mitochondrial tRNATrp can recognize the nonsense codon UGA
Nature, 1980DNA sequence analysis of mitochondrial genes that code for some mitochondrial proteins has suggested that the opal terminator, UGA, is used as a sense codon in mitochondria. The complete sequences of both the yeast and human genes coding for cytochrome oxidase subunit II contain UGA codons in the reading frame.
N C, Martin +4 more
openaire +2 more sources
Identification of nonsense codons in yeast
Journal of Molecular Biology, 1969Abstract Two nonsense codons have been found in Saccharomyces cerevisiae . The codons differ by a single base and only one contains guanine. Accepting the universality of the genetic code, one can deduce that these are amber and ochre codons since there exist suppressors capable of acting upon either class of nonsense alleles.
openaire +2 more sources
Codon context effects on nonsense suppression in human cells
Biochemical Society Transactions, 1993Carter, P. W., Hartkus, J. M. and Calvo, J. M. (1986) Proc.Natl.Acad.Sci. U.S.A.83,8127-8131 Gabain, A. v., Helasco, J. G.. Schottel, J. I,., Chang, A. C. Y. and Cohen. S. N. (1983) Proc. Natl. Acad. Sci. [J.S.A. 80, 653-657 Petersen, C. (1987) MGG Mol. Gen. Genet. 209, 179187 Spaniard. K. A., Chen, K., Walker, J. K. and van Lhin, J.
R, Martin +3 more
openaire +2 more sources
Nonsense-codon-mediated decay in human hereditary complement C3 deficiency
Immunogenetics, 2004C3 occupies a central position in the complement pathway, mediating such diverse functions as convertase activity, opsonization and anaphylotoxin production. The deficiency of this protein is a rare autosomal recessive inherited disease, characterized by severe recurrent infections and immune complex disorders.
Edimara S, Reis +2 more
openaire +2 more sources
Effects of surrounding sequence on the suppression of nonsense codons
Journal of Molecular Biology, 1983Using a lacI-Z fusion system, we have determined the efficiency of suppression of nonsense codons in the I gene of Escherichia coli by assaying beta-galactosidase activity. We examined the efficiency of four amber suppressors acting on 42 different amber (UAG) codons at known positions in the I gene, and the efficiency of a UAG suppressor at 14 ...
MILLER J. H, ALBERTINI, ALESSANDRA
openaire +2 more sources