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Translation termination codons in protein synthesis and disease
2022Fidelity of protein synthesis, a process shaped by several mechanisms involving specialized ribosome regions and external factors, ensures the precise reading of sense as well as stop codons (UGA, UAG, UAA), which are usually localized at the 3' of mRNA and drive the release of the polypeptide chain.
Lombardi S. +3 more
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Suppression of Translation Frameshift by Upstream Termination Codon
Biochemical and Biophysical Research Communications, 1996Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting.
A, Honda, S, Nishimura
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Premature Termination Codon-Bearing mRNA Mediates Genetic Compensation Response
Zebrafish, 2020The genetic compensation response (GCR), triggered by deleterious mutations but not by gene knockdown, has been proposed to explain many phenotypic discrepancies between gene-knockout and gene-knockdown models. GCRs have been observed in many model organisms from mice to Arabidopsis.
Zhipeng, Ma, Jun, Chen
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Factors Affecting Readthrough of Natural Versus Premature Termination Codons
2023Nonsense mutations occur within the open-reading frame of a gene resulting in a premature termination codon (PTC). PTC-containing mRNAs can either be degeraded or cause premature translation termination producing a truncated protein that can be either nonfunctional or toxic.
Avigail, Beryozkin +3 more
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The UGA codon in vitro: Chain termination and suppression
Journal of Molecular Biology, 1969Abstract UGA suppressor-dependent mutants of bacteriophage f2 were isolated at low frequency after fluouracil mutagenesis. One was mutant in the viral polymerase cistron, and six of the remainder were defective in the maturation protein cistron. No coat protein mutants have been found.
P, Model, R E, Webster, N D, Zinder
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Suppression of termination codons in higher eukaryotes
Trends in Biochemical Sciences, 1985Abstract Introduction of nonsense suppressor tRNAs or genes encoding nonsense suppressor tRNAs into cells of higher eukaryotes shows that these tRNAs or tRNA gene products suppress the corresponding termination codons, UAA, UAG and UGA. On the other hand, most of the natural suppression in higher eukaryotes involves misreading of termination codons ...
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Programmed Readthrough of Translational Termination Codons
1997If alternative decoding events occur only during a translational pause, then any translational pause of sufficient duration could cause an aberrant event to occur. Of course, all translational pauses do not since much more is required than simply a translational pause.
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Leaky UAG termination codon in tobacco mosaic virus RNA
Nature, 1978THE RNA of tobacco mosaic virus (TMV) can be translated in various cell-free systems1–3 and in amphibian oocytes4, to yield two large polypeptides of molecular weights (MW) approximately 110,000 (110K) and 160,000 (160K). Products of the same sizes are found in infected plants2,5 and protoplasts6 and they are probably components of the viral replicase7,
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Blepharisma Uses UAA as a termination codon
Naturwissenschaften, 1993A, Liang, K, Heckmann
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Selective Use of Termination Codons and Variations in Codon Choice
2018Paul M. Sharp +3 more
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