Results 91 to 100 of about 593,183 (294)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Cloning and analysis of genome of transmissible gastroenteritis virus SC-Y strain
浙江大学学报. 农业与生命科学版, 2007 Sixteen pair of primers covering the whole genome of TGEV were devised according to the published sequences, 16 cDNA fragments were amplified by RT-PCR. The amplified fragments were further cloned and sequenced. The genome of SC-Y strain was assembled by
SONG Zhen-hui, GUO Wan-zhu, YIN Hua-ping
doaj +1 more source
Stochastic kinetics of ribosomes: single motor properties and collective behavior [PDF]
, 2009 Synthesis of protein molecules in a cell are carried out by ribosomes. A ribosome can be regarded as a molecular motor which utilizes the input chemical energy to move on a messenger RNA (mRNA) track that also serves as a template for the polymerization ...
A. S. Spirin +11 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Genotype-Phenotype Correlations of β-Thalassemia Mutations in an Azerbaijani Population
Turkish Journal of Hematology, 2017 β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-
Chingiz Asadov +5 more
doaj +1 more source
Mechanism of Virus Attenuation by Codon Pair Deoptimization
Cell Reports, 2020 Summary: Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that leads to attenuation is unknown. The strategy involves synthetic recoding of viral genomes that alters the positions of synonymous codons, thereby ...
Nicole Groenke +10 more
doaj +1 more source
Optimized expression of the Starmerella bombicola lactone esterase in Pichia pastoris through temperature adaptation, codon-optimization and co-expression with HAC1 [PDF]
, 2018 The Starmerella bombicola lactone esterase (SBLE) is a novel enzyme that, in vivo, catalyzes the intramolecular esterification (lactonization) of acidic sophorolipids in an aqueous environment.
Ciesielska, Katarzyna +8 more
core +2 more sources
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Ordering events in a developing genetic code
RNA BiologyPreexisting partial genetic codes can fuse to evolve towards the complete Standard Genetic Code (SGC). Such code fusion provides a path of ‘least selection’, readily generating precursor codes that resemble the SGC.
Michael Yarus
doaj +1 more source
Control of ribosome traffic by position-dependent choice of synonymous codons
, 2013 Messenger RNA encodes a sequence of amino acids by using codons. For most amino acids there are multiple synonymous codons that can encode the amino acid.
Mitarai, Namiko, Pedersen, Steen
core +1 more source