Codon-based Z-test of purifying selection in LAGLIDADG ORFs of Scleractinia and Corallimorpharia.
, 2017 Codon-based Z-test of purifying selection in LAGLIDADG ORFs of Scleractinia and Corallimorpharia.
Jörn Kalinowski (23807) +7 more
core +1 more source
Impact of the Specific Mutation in KRAS Codon 12 Mutated Tumors on Treatment Efficacy in Patients with Metastatic Colorectal Cancer Receiving Cetuximab-Based First-Line Therapy: A Pooled Analysis of Three Trials [PDF]
, 2012 Purpose: This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC).
Zielinski, Christoph C. +12 more
core +1 more source
The Involvement of YNR069C in Protein Synthesis in the Baker’s Yeast, Saccharomyces cerevisiae
BiologyMaintaining translation fidelity is a critical step within the process of gene expression. It requires the involvement of numerous regulatory elements to ensure the synthesis of functional proteins. The efficient termination of protein synthesis can play
Sarah Takallou +7 more
doaj +1 more source
Measurement of average decoding rates of the 61 sense codons in vivo
eLife, 2014 Most amino acids can be encoded by several synonymous codons, which are used at unequal frequencies. The significance of unequal codon usage remains unclear. One hypothesis is that frequent codons are translated relatively rapidly.
Justin Gardin +5 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Codon-triplet context unveils unique features of the protein coding genome-8
, 2011 Copyright information:Taken from "Codon-triplet context unveils unique features of the protein coding genome"http://www.biomedcentral.com/1471-2164/8/444BMC Genomics 2007;8():444-444.Published online 29 Nov 2007PMCID:PMC2244636.
Laura Carreto (34863) +6 more
core +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Codon-triplet context unveils unique features of the protein coding genome-1
, 2011 Copyright information:Taken from "Codon-triplet context unveils unique features of the protein coding genome"http://www.biomedcentral.com/1471-2164/8/444BMC Genomics 2007;8():444-444.Published online 29 Nov 2007PMCID:PMC2244636.is by analyzing four ...
Laura Carreto (34863) +6 more
core +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Codon-triplet context unveils unique features of the protein coding genome-0
, 2011 Copyright information:Taken from "Codon-triplet context unveils unique features of the protein coding genome"http://www.biomedcentral.com/1471-2164/8/444BMC Genomics 2007;8():444-444.Published online 29 Nov 2007PMCID:PMC2244636.is by analyzing four ...
Laura Carreto (34863) +6 more
core +1 more source