Results 81 to 90 of about 593,183 (294)

Environmental shaping of codon usage and functional adaptation across microbial communities. [PDF]

, 2013
Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the ...
Achtman, Altschul, Arumugam, Boto, Botzman, Bruggemann, Burke, Caro-Quintero, Chen, Diene, Donner, Foerstner, Forsberg, Gill, Hershberg, Horvath, Hunyadkurti, Huson, Ikemura, István Nagy, Jensen, Johnson, Kanaya, Kanehisa, Karlin, Keeling, Keller, Kristian Vlahoviček, Kuo, Larimer, Malmstrom, Martin, Maša Roller, McDaniel, McDowell, Mira, Myers, Oda, Plotkin, R Development Core Team, Retchless, Rocha, Sharp, Sharp, Sowell, Staley, Supek, Supek, Tatusov, Tettelin, Tina Perica, Tringe, Tuller, Tuller, Tuller, Turnbaugh, Tyson, Vedran Lucić, Venter, Verberkmoes, Vieira-Silva, Whitman, Willenbrock, Wilmes   +63 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Thermodynamic and kinetic insights into stop codon recognition by release factor 1. [PDF]

, 2014
Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent crystal structures showed that stop codon recognition is achieved mainly through a network of ...
Joseph, Simpson, Mathew, Merrill A, Trappl, Krista   +2 more
core  

Ribosome traffic on mRNAs maps to gene ontology : genome-wide quantification of translation initiation rates and polysome size regulation [PDF]

, 2013
Peer reviewedPublisher ...
Ciandrini, Luca, Romano, M Carmen, Stansfield, Ian   +2 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Enterovirus A Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade

Frontiers in Cellular and Infection Microbiology, 2022
Enterovirus A (EV-A) species cause hand, foot and mouth disease (HFMD), threatening the health of young children. Understanding the mutual codon usage pattern of the virus and its host(s) has fundamental and applied values.
Liyan Zeng, Ming Chen, Min Wang, Liuyao Zhu, Jingjing Yan, Xiaoyan Zhang, Jianqing Xu, Shuye Zhang   +7 more
doaj   +1 more source

Sum rules of codon usage probabilities

, 2002
In the crystal basis model of the genetic code, it is deduced that the sum of usage probabilities of the codons with C and A in the third position for the quartets and/or sextets is independent of the biological species for vertebrates. A comparison with
A Sciarrino, Akashi, Aota, Bernardi, Bernardi, Bernardi, Bulmer, Chiusano, Frappat, Frappat, Frappat, Gouy, Huynen, Ikemura, Ikemura, Knight, L Frappat, Osawa, Osawa, P Sorba, Sharp, Zeeberg   +21 more
core   +2 more sources

Translation conditional models for protein coding sequences [PDF]

, 2000
A coding sequence is defined as a DNA sequence coding the primary structure of a protein (a polypeptide). Such a sequence must satisfy a specific constraint, which consists in coding a functional protein, As the genetic code is degenerated, there exists,
Mathé, Catherine, Rodolphe, François
core   +2 more sources

Rare Codons Cluster

PLoS ONE, 2008
Most amino acids are encoded by more than one codon. These synonymous codons are not used with equal frequency: in every organism, some codons are used more commonly, while others are more rare. Though the encoded protein sequence is identical, selective pressures favor more common codons for enhanced translation speed and fidelity.
Thomas F Clarke, Patricia L Clark
openaire   +4 more sources