Results 61 to 70 of about 593,183 (294)
The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]
, 2011 Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y. +2 more
core +2 more sources
Codon distributions in DNA [PDF]
Physical Review E, 2001 31 pages, 5 ...
Som, A. +3 more
openaire +3 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Big data in breast cancer: Towards precision treatment
Digital HealthBreast cancer is the most prevalent and deadliest cancer among women globally, representing a major threat to public health. In response, the World Health Organization has established the Global Breast Cancer Initiative framework to reduce breast cancer ...
Hao Zhang +5 more
doaj +1 more source
Microbial Cell Factories, 2021 Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias.
Yide Huang +6 more
doaj +1 more source
Distinct responses to rare codons in select Drosophila tissues
eLife, 2022 Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression.
Scott R Allen +8 more
doaj +1 more source
Back-translation for discovering distant protein homologies [PDF]
, 2009 Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin.
A. Pedersen +17 more
core +10 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Ribosome signatures aid bacterial translation initiation site identification [PDF]
, 2017 Background: While methods for annotation of genes are increasingly reliable, the exact identification of translation initiation sites remains a challenging problem.
Chyżyńska, Katarzyna +5 more
core +2 more sources
An extreme codon preference strategy: codon reassignment. [PDF]
Molecular Biology and Evolution, 1991 We argue that in animal mitochondria codon reassignments, such as those for AGA and AGG from arginine to serine or of AUA from isoleucine to methionine, are the result of an interplay between biased mutational forces and selective ones. In particular, there is a marked tendency for animal mitochondria to have very small genomes and to minimize their ...
G E, Andersson, C G, Kurland
openaire +2 more sources