Results 51 to 60 of about 494,112 (301)
The Ccr4-Not complex monitors the translating ribosome for codon optimality
Science, 2019 Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
R. Buschauer +16 more
semanticscholar +1 more source
Codon optimality is a major determinant of mRNA stability
Cell, 2015 Messenger RNA degradation represents a critical regulated step in gene expression. While the major pathways in turnover have been identified, accounting for disparate half-lives has been elusive.
Vladimir Presnyak +10 more
semanticscholar +1 more source
Solid Phase Assembly of Fully Protected Trinucleotide Building Blocks for Codon-Based Gene Synthesis
Applied Sciences, 2019 The use of pre-formed trinucleotides, representing codons of the 20 canonical amino acids, for oligonucleotide-directed mutagenesis offers the advantage of controlled randomization and generation of “smart libraries”. We here present a method
Ruth Suchsland +3 more
doaj +1 more source
Developing and evaluating a pollination systems knowledge assessment in a multidisciplinary course
International Journal of STEM Education, 2022 Background Although pollinators play an integral role in human well-being, their continued global decline reflects the need to provide and evaluate general pollinator knowledge to promote their conservation.
P. Citlally Jimenez +3 more
doaj +1 more source
bioRxiv, 2019 Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.
J. Wangen, R. Green
semanticscholar +1 more source
Acta Limnologica Brasiliensia, 2020 : Aim Structural changes in phytoplankton was evaluated in one ultraoligotrophic and two oligotrophic cascading reservoirs during two climatic periods (austral winter and summer) of 2014. Changes in phytoplankton biomass, species composition, and codons
Ana Margarita Loaiza-Restano +3 more
doaj +1 more source
Converting nonsense codons into sense codons by targeted pseudouridylation [PDF]
Nature, 2011 All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon. Here, we demonstrate that pseudouridylation (conversion of uridine into pseudouridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vitro and in vivo.
John, Karijolich, Yi-Tao, Yu
openaire +2 more sources
Synonymous but not the same: the causes and consequences of codon bias
Nature reviews genetics, 2010 Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology.
J. Plotkin, Grzegorz Kudla
semanticscholar +1 more source
Strategies and Patterns of Codon Bias in Molluscum Contagiosum Virus
Pathogens, 2021 Trends associated with codon usage in molluscum contagiosum virus (MCV) and factors governing the evolution of codon usage have not been investigated so far.
Rahul Raveendran Nair +4 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Many proteins that are incapable of refolding in vitro nevertheless fold efficiently to their native state in the cell. This suggests that more information than the amino acid sequence is required to properly fold these proteins.
Ian M. Walsh +4 more
semanticscholar +1 more source