Codon usage tabulated from international DNA sequence databases: status for the year 2000
Nucleic Acids Research, 2000 Takashi Gojobori +2 more
exaly +2 more sources
Geographical distribution of Brucella melitensis inferred from rpoB gene variation
Journal of Infection in Developing Countries, 2017 Introduction: Currently available tests have limitations for the identification of Brucella species and strains, and their genetic lineage. The genome sequence of the rpoB gene encoding the β-subunit of DNA-dependent RNA polymerase was investigated for ...
Kim-Kee Tan +7 more
doaj +1 more source
A code within the genetic code: codon usage regulates co-translational protein folding
Cell Communication and Signaling, 2020 The genetic code is degenerate, and most amino acids are encoded by two to six synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a universal feature of all genomes examined.
Yi Liu
semanticscholar +1 more source
Codon optimization with deep learning to enhance protein expression
Scientific Reports, 2020 Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes.
Hongguang Fu +8 more
semanticscholar +1 more source
Candidate essential genes in Burkholderia cenocepacia J2315 identified by genome-wide TraDIS
Frontiers in Microbiology, 2016 Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. However, antibiotic therapy rarely results in complete eradication of the pathogen due to its intrinsic resistance to many clinically available ...
Yee-Chin Wong +6 more
doaj +1 more source
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments
Nucleic Acids Res., 2006 PAL2NAL is a web server that constructs a multiple codon alignment from the corresponding aligned protein sequences. Such codon alignments can be used to evaluate the type and rate of nucleotide substitutions in coding DNA for a wide range of ...
M. Suyama, D. Torrents, P. Bork
semanticscholar +1 more source
Intracellular management of information: from DNA to proteins
tripleC: Communication, Capitalism & Critique, 2009 The living features of cells constitute an information flow from a central database, the nuclear DNA, to molecular effectors, proteins, which are synthesised in the cytoplasm.
Juan M. Lara
doaj +1 more source
Analysis of p53 codon 72 polymorphism and HPV 5,8 E6 oncoprotein expression in Basal cell carcinoma in Basrah [PDF]
The Medical Journal of Basrah University, 2016 Background: Two polymorphic forms of the p53 gene that codes either for Arginine or proline at codon 72 were identified, However, this individual might have one of the three genotypes: Arginine/Arginine, Proline/Proline or Arginine /Proline.
Wasan AA. Sayhood +2 more
doaj +1 more source
Cell Discovery, 2018 N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch.
Y. Yue +16 more
semanticscholar +1 more source
Characterization of the mIF4G Domains in the RNA Surveillance Protein Upf2p
Current Issues in Molecular Biology, 2023 Thirty percent of all mutations causing human disease generate mRNAs with premature termination codons (PTCs). Recognition and degradation of these PTC-containing mRNAs is carried out by the mechanism known as nonsense-mediated mRNA decay (NMD).
Edgardo M. Colón +5 more
doaj +1 more source