Results 21 to 30 of about 445,931 (266)
Codon Usage Domains over Bacterial Chromosomes [PDF]
, 2006 The geography of codon bias distributions over prokaryotic genomes and its impact upon chromosomal organization are analyzed. To this aim, we introduce a clustering method based on information theory, specifically designed to cluster genes according to ...
Danchin, Antoine +11 more
core +2 more sources
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. [PDF]
, 2008 BACKGROUND: Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression.
Horn, David +2 more
core +1 more source
Characterization of the mIF4G Domains in the RNA Surveillance Protein Upf2p
Current Issues in Molecular Biology, 2023 Thirty percent of all mutations causing human disease generate mRNAs with premature termination codons (PTCs). Recognition and degradation of these PTC-containing mRNAs is carried out by the mechanism known as nonsense-mediated mRNA decay (NMD).
Edgardo M. Colón +5 more
doaj +1 more source
Stops making sense: translational trade-offs and stop codon reassignment [PDF]
, 2011 Background Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons
Steven C Le Comber +28 more
core +2 more sources
Effects of Arbovirus Multi-Host Life Cycles on Dinucleotide and Codon Usage Patterns
Viruses, 2019 Arthropod-borne viruses (arboviruses) of vertebrates including dengue, zika, chikungunya, Rift Valley fever, and blue tongue viruses cause extensive morbidity and mortality in humans, agricultural animals, and wildlife across the globe.
Nicole R. Sexton, Gregory D. Ebel
doaj +1 more source
Environmental shaping of codon usage and functional adaptation across microbial communities. [PDF]
, 2013 Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the ...
Roller, Masa +4 more
core +1 more source
, 2023 Full Changelog: https://github.com/alondmnt/codon-bias/compare/0.3.0...v0.3.
Alon Diament
core +1 more source
Clinical and Translational Medicine, 2023 Background Translation dysregulation plays a crucial role in tumourigenesis and cancer progression. Oncogenic translation relies on the stability and availability of tRNAs for protein synthesis, making them potential targets for cancer therapy.
Peng Li +4 more
doaj +1 more source
Codon-optimized 16S rRNA methyltransferase resistance gene sequence.
, 2023 Codon-optimized 16S rRNA methyltransferase resistance gene sequence.
Christopher E. Morgan (11269227) +13 more
core +1 more source
A Novel Mutation of PARK-2 Gene in a Patient with Early-onset Parkinson’s Disease
Oman Medical Journal, 2020 Between 3–5% of all patients with Parkinson’s disease (PD) have onset before the age of 40 years, which is likely related to genetic causes. Parkin gene mutations are the most common mutations, which are associated with autosomal recessive early-onset PD.
Tariq Alafifi +4 more
doaj +1 more source